Publikationen

Nguyen, K. L., Bhatt, I. J., Gupta, S., Showkat, N., Swanson, K. A., Fischer, R., Kontermann, R. E., Pfizenmaier, K., Bracchi-Ricard, V., & Bethea, J. R. (2024). Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis. Brain research bulletin, 207, 110885--110885. https://doi.org/10.1016/j.brainresbull.2024.110885

Klein, C., Brinkmann, U., Reichert, J. M., & Kontermann, R. E. (2024). The present and future of bispecific antibodies for cancer therapy. Nature Reviews Drug Discovery, 23(4), Article 4. https://doi.org/10.1038/s41573-024-00896-6

Köhler, A. R., Haußer, J., Harsch, A., Bernhardt, S., Häußermann, L., Brenner, L.-M., Lungu, C., Olayioye, M. A., Bashtrykov, P., & Jeltsch, A. (2024). Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells. Cell Reports Methods, 4(4), Article 4. https://doi.org/10.1016/j.crmeth.2024.100739

Beigl, T. B., Paul, A., Fellmeth, T. P., Nguyen, D., Barber, L., Weller, S., Schäfer, B., Gillissen, B. F., Aulitzky, W. E., Kopp, H.-G., Rehm, M., Andrews, D. W., Pluhackova, K., & Essmann, F. (2024). BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains. EMBO reports, 25(9), Article 9. https://doi.org/10.1038/s44319-024-00206-6

Schlett, K., Oueslati Morales, C. O., Bencsik, N., & Hausser, A. (2024). Getting smart – Deciphering the neuronal functions of protein kinase D. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1871(7), Article 7. https://doi.org/10.1016/j.bbamcr.2024.119812

Boccellato, C., & Rehm, M. (2024). TRAIL-induced apoptosis and proteasomal activity – Mechanisms, signalling and interplay. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 119688. https://doi.org/10.1016/j.bbamcr.2024.119688

Brenner, L.-M., Meyer, F., Yang, H., Köhler, A. R., Bashtrykov, P., Guo, M., Jeltsch, A., Lungu, C., & Olayioye, M. A. (2024). Repeat DNA methylation is modulated by adherens junction signaling. Communications Biology, 7(1), Article 1. https://doi.org/10.1038/s42003-024-05990-4

Frey, Y., Lungu, C., Meyer, F., Hauth, F., Hahn, D., Kersten, C., Heller, V., Franz-Wachtel, M., Macek, B., Barsukov, I., & Olayioye, M. A. (2024). Regulation of the DLC3 tumor suppressor by a novel phosphoswitch. iScience, 27(7), Article 7. https://doi.org/10.1016/j.isci.2024.110203

Gali, A., Bijnsdorp, I. V., Piersma, S. R., Pham, T. V., Gutiérrez-Galindo, E., Kühnel, F., Tsolakos, N., Jimenez, C. R., Hausser, A., & Alexopoulos, L. G. (2024). Protein Kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines. iScience, 108958. https://doi.org/10.1016/j.isci.2024.108958

Pegoretti, V., Bauer, J., Fischer, R., Paro, I., Douwenga, W., Kontermann, R. E., Pfizenmaier, K., Houben, E., Broux, B., Hellings, N., Baron, W., Laman, J. D., & Eisel, U. L. M. (2023). Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS. Journal of neuroinflammation, 20(1), Article 1. https://doi.org/10.1186/s12974-023-02785-y

Fiedler, T., Fairless, R., Pichi, K., Fischer, R., Richter, F., Kontermann, R. E., Pfizenmaier, K., Diem, R., & Williams, S. K. (2023). Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis. Journal of neuroinflammation, 20(1), Article 1. https://doi.org/10.1186/s12974-023-02784-z

Guttà, C., Morhard, C., & Rehm, M. (2023). Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer. PLOS Computational Biology, 19(4), Article 4. https://doi.org/10.1371/journal.pcbi.1011035

Liang, K. L., Roels, J., Lavaert, M., Putteman, T., Boehme, L., Tilleman, L., Velghe, I., Pegoretti, V., Van de Walle, I., Sontag, S., Vandewalle, J., Vandekerckhove, B., Leclercq, G., Van Vlierberghe, P., Libert, C., Van Nieuwerburgh, F., Fischer, R., Kontermann, R. E., Pfizenmaier, K., … Taghon, T. (2023). Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nature Immunology. https://doi.org/10.1038/s41590-022-01417-6

Abassi, L., Bertoglio, F., Mačak Šafranko, Ž., Schirrmann, T., Greweling-Pils, M., Seifert, O., Khan, F., Katzmarzyk, M., Jacobsen, H., Gödecke, N., Heine, P. A., Frenzel, A., Nowack, H., Dübel, S., Kurolt, I.-C., Kontermann, R. E., Markotić, A., Schubert, M., Hust, M., & Čičin-Šain, L. (2023). Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns. Viruses, 15(11), Article 11. https://doi.org/10.3390/v15112153

Kühl, L., Schäfer, A. K., Kraft, S., Aschmoneit, N., Kontermann, R. E., & Seifert, O. (2023). eIg-based bispecific T-cell engagers targeting EGFR: Format matters. mAbs, 15(1), Article 1. https://doi.org/10.1080/19420862.2023.2183540

Fullstone, G. (2023). Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs. In Methods in Molecular Biology (S. 191--212). Springer US. https://doi.org/10.1007/978-1-0716-3008-2_9

Lungu, C., Meyer, F., Hörning, M., Steudle, J., Braun, A., Noll, B., Benz, D., Fränkle, F., Schmid, S., Eisler, S. A., Olayioye, M. A., & Monilola Olayioye, C. A. (2023). Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport. Traffic. https://doi.org/10.1111/TRA.12880

Steinlein, S., Essmann, F., Ghilardi, A. F., Horn, H., Schüler, J., Hausser, A., Sun, L., Ott, G., & Kalla, C. (2023). Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in oncology, 13, 1190988--1190988. https://doi.org/10.3389/fonc.2023.1190988

Gutiérrez-Galindo, E., Yilmaz, Z. H., & Hausser, A. (2023). Membrane trafficking in breast cancer progression: protein kinase D comes into play. Frontiers in cell and developmental biology, 11, 1173387--1173387. https://doi.org/10.3389/fcell.2023.1173387

Ortí-Casañ, N., Boerema, A. S., Köpke, K., Ebskamp, A., Keijser, J., Zhang, Y., Chen, T., Dolga, A. M., Broersen, K., Fischer, R., Pfizenmaier, K., Kontermann, R. E., & Eisel, U. L. M. (2023). The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration. Scientific reports, 13(1), Article 1. https://doi.org/10.1038/s41598-023-36846-2

Müller, D. (2023). Targeting Co-Stimulatory Receptors of the TNF Superfamily for Cancer Immunotherapy. BioDrugs, 37(1), Article 1. https://doi.org/10.1007/s40259-022-00573-3

Reinhardt, R., Hirzel, K., Link, G., Eisler, S. A., Hägele, T., Parson, M. A. H., Burke, J. E., Hausser, A., & Leonard, T. A. (2023). PKD autoinhibition in trans regulates activation loop autophosphorylation in cis. Proceedings of the National Academy of Sciences, 120(7), Article 7. https://doi.org/10.1073/pnas.2212909120

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., … Galluzzi, L. (2023). Apoptotic cell death in disease---Current understanding of the NCCD 2023. Cell Death & Differentiation, 30(5), Article 5. https://doi.org/10.1038/s41418-023-01153-w

Ignácz, A., Nagy-Herczeg, D., Hausser, A., & Schlett, K. (2023). Dendritic effects of genetically encoded actin labelling probes in cultured hippocampal neurons. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e22-08-0331

Katiyar, P., Schwenck, J., Frauenfeld, L., Divine, M. R., Agrawal, V., Kohlhofer, U., Gatidis, S., Kontermann, R., Königsrainer, A., Quintanilla-Martinez, L., la Fougère, C., Schölkopf, B., Pichler, B. J., & Disselhorst, J. A. (2023). Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data. Nature biomedical engineering, 10.1038/s41551-023-01047–01049--. https://doi.org/10.1038/s41551-023-01047-9

Müller, D. (2022). Optimized CD19/CD22/CD3 antibody. Blood, 140(16), Article 16. https://doi.org/10.1182/blood.2022018081

Aschmoneit, N., Kocher, K., Siegemund, M., Lutz, M. S., Kühl, L., Seifert, O., & Kontermann, R. E. (2022). Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc). Oncoimmunology, 11(1), Article 1. https://doi.org/10.1080/2162402X.2022.2028961

Del Mistro, G., Riemann, S., Schindler, S., Beissert, S., Kontermann, R. E., Ginolhac, A., Halder, R., Presta, L., Sinkkonen, L., Sauter, T., & Kulms, D. (2022). Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma. Cell death & disease, 13(1), Article 1. https://doi.org/10.1038/s41419-022-04502-8

Rau, A., Janssen, N., Kühl, L., Sell, T., Kalmykova, S., Mürdter, T. E., Dahlke, M.-H., Sers, C., Morkel, M., Schwab, M., Kontermann, R. E., & Olayioye, M. A. (2022). Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancerTriple HER blockade in CRC. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-21-0818

Dilchert, J., Hofmann, M., Unverdorben, F., Kontermann, R., & Bunk, S. (2022). Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules. Antibodies, 11(2), Article 2. https://doi.org/10.3390/antib11020034

Guttà, C., Morhard, C., & Rehm, M. (2022). T-GAN-D: a GAN-based classifier for breast cancer                    prognostication. Zenodo. https://doi.org/10.5281/zenodo.7151831

Bencsik, N., Oueslati Morales, C. O., Hausser, A., & Schlett, K. (2022). Endocytosis of AMPA receptors: Role in neurological conditions. In Progress in Molecular Biology and Translational Science. Academic Press. https://doi.org/10.1016/bs.pmbts.2022.09.007

Mora-Molina, R., Stöhr, D., Rehm, M., & López-Rivas, A. (2022). cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. Cell Death & Disease, 13(2), Article 2. https://doi.org/10.1038/s41419-022-04574-6

Hagenlocher, C., Siebert, R., Taschke, B., Wieske, S., Hausser, A., & Rehm, M. (2022). ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery, 8(1), Article 1. https://doi.org/10.1038/s41420-022-00830-y

Guttà, C., Morhard, C., & Rehm, M. (2022). Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer. In medRxiv. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/2022.10.07.22280776

Boccellato, C., & Rehm, M. (2022). Glioblastoma, from disease understanding towards optimal cell-based in vitro models. Cellular Oncology. https://doi.org/10.1007/s13402-022-00684-7

Seifert, O., & Kontermann, R. E. (2022). GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments. Molecules (Basel, Switzerland), 27(10), Article 10. https://doi.org/10.3390/molecules27103272

Frey, Y., Franz-Wachtel, M., Macek, B., & Olayioye, M. A. (2022). Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Scientific Reports 2022 12:1, 12(1), Article 1. https://doi.org/10.1038/s41598-022-08844-3

Kühl, L., Aschmoneit, N., Kontermann, R. E., & Seifert, O. (2022). The eIg technology to generate Ig-like bispecific antibodies. mAbs, 14(1), Article 1. https://doi.org/10.1080/19420862.2022.2063043

Vera, J., Lai, X., Baur, A., Erdmann, M., Gupta, S., Guttà, C., Heinzerling, L., Heppt, M. V., Kazmierczak, P. M., Kunz, M., Lischer, C., Pützer, B. M., Rehm, M., Ostalecki, C., Retzlaff, J., Witt, S., Wolkenhauer, O., & Berking, C. (2022). Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence. Briefings in Bioinformatics. https://doi.org/10.1093/BIB/BBAC433

Ludwig-Słomczyńska, A. H., & Rehm, M. (2022). Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases. Obesity. https://doi.org/10.1002/OBY.23424

Lindner, A. U., Salvucci, M., McDonough, E., Cho, S., Stachtea, X., O’Connell, E. P., Corwin, A. D., Santamaria-Pang, A., Carberry, S., Fichtner, M., Van Schaeybroeck, S., Laurent-Puig, P., Burke, J. P., McNamara, D. A., Lawler, M., Sood, A., Graf, J. F., Rehm, M., Dunne, P. D., … Prehn, J. H. M. (2021). An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell Death & Differentiation. https://doi.org/10.1038/s41418-021-00895-9

Aschmoneit, N., Steinlein, S., Kühl, L., Seifert, O., & Kontermann, R. E. (2021). A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells. Scientific reports, 11(1), Article 1. https://doi.org/10.1038/S41598-021-93351-0

Juric, V., Düssmann, H., Lamfers, M. L. M., Prehn, J. H. M., Rehm, M., & Murphy, B. M. (2021). Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells 2021, Vol. 10, Page 1182, 10(5), Article 5. https://doi.org/10.3390/cells10051182

Richter, F., Williams, S. K., John, K., Huber, C., Vaslin, C., Zanker, H., Fairless, R., Pichi, K., Marhenke, S., Vogel, A., Dhaen, M.-A., Herrmann, S., Herrmann, A., Pfizenmaier, K., Bantel, H., Diem, R., Kontermann, R. E., & Fischer, R. (2021). The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705485

Ehlers, W., Morrison (Rehm), M., Schröder, P., Stöhr, D., & Wagner, A. (2021). Multiphasic modelling and computation of metastatic lung-cancer cell proliferation and atrophy in brain tissue based on experimental data. Biomechanics and Modeling in Mechanobiology. https://doi.org/10.1007/s10237-021-01535-4

Pollak, N., Lindner, A., Imig, D., Kuritz, K., Fritze, J. S., Decker, L., Heinrich, I., Stadager, J., Eisler, S., Stöhr, D., Allgöwer, F., Scheurich, P., & Rehm, M. (2021). Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis. Journal of cell science, jcs.258966--. https://doi.org/10.1242/jcs.258966

Aschmoneit, N., Kühl, L., Seifert, O., & Kontermann, R. E. (2021). Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release. Journal for immunotherapy of cancer, 9(11), Article 11. https://doi.org/10.1136/jitc-2021-003616

Hellwig, C. T., Delgado, M. E., Skoko, J., Dyck, L., Hanna, C., Wentges, A., Langlais, C., Hagenlocher, C., Mack, A., Dinsdale, D., Cain, K., MacFarlane, M., & Rehm, M. (2021). Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death & Differentiation 2021, 1--9. https://doi.org/10.1038/s41418-021-00843-7

Boccellato, C., Kolbe, E., Peters, N., Juric, V., Fullstone, G., Verreault, M., Idbaih, A., Lamfers, M. L. M., Murphy, B. M., & Rehm, M. (2021). Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell Death & Disease, 12(7), Article 7. https://doi.org/10.1038/s41419-021-03927-x

Massafra, V., Tundo, S., Dietzig, A., Ducret, A., Jost, C., Klein, C., Kontermann, R. E., Knoetgen, H., Steegmaier, M., Romagnani, A., & Nagel, Y. A. (2021). Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000252

Bethea, J. R., & Fischer, R. (2021). Role of peripheral immune cells for development and recovery of chronic pain. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.641588

Brinkmann, U., & Kontermann, R. E. (2021). Bispecific antibodies. Science, 372(6545), Article 6545. https://doi.org/10.1126/science.abg1209

Oueslati Morales, C. O., Ignácz, A., Bencsik, N., Sziber, Z., Rátkai, A. E., Lieb, W. S., Eisler, S. A., Szűcs, A., Schlett, K., & Hausser, A. (2021). Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic, n/a(n/a), Article n/a. https://doi.org/10.1111/tra.12819

Siegemund, M., Oak, P., Hansbauer, E.-M., Allersdorfer, A., Utschick, K., Winter, A., Grasmüller, C., Galler, G., Mayer, J.-P., Weiche, B., Prassler, J., Kontermann, R. E., & Rothe, C. (2021). Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Frontiers in pharmacology, 12, 759337--759337. https://doi.org/10.3389/fphar.2021.759337

McCann, C., Matveeva, A., McAllister, K., Sessler, T., Fichtner, M., Carberry, S., Rehm, M., Prehn, J. H. M., & Longley, D. B. (2021). Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. The FEBS Journal, febs.15801. https://doi.org/10.1111/febs.15801

Rau, A., Kocher, K., Rommel, M., Kühl, L., Albrecht, M., Gotthard, H., Aschmoneit, N., Noll, B., Olayioye, M. A., Kontermann, R. E., & Seifert, O. (2021). A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3. mAbs, 13(1), Article 1. https://doi.org/10.1080/19420862.2021.1902034

Juric, V., Hudson, L., Fay, J., Richards, C. E., Jahns, H., Verreault, M., Bielle, F., Idbaih, A., Lamfers, M. L. M., Hopkins, A. M., Rehm, M., & Murphy, B. M. (2021). Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Cell Death & Disease 2021 12:8, 12(8), Article 8. https://doi.org/10.1038/s41419-021-04050-7

Papazian, I., Tsoukala, E., Boutou, A., Karamita, M., Kambas, K., Iliopoulou, L., Fischer, R., Kontermann, R. E., Denis, M. C., Kollias, G., Lassmann, H., & Probert, L. (2021). Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. Journal of neuroinflammation, 18(1), Article 1. https://doi.org/10.1186/s12974-021-02200-4

Krishna Moorthy, N., Seifert, O., Eisler, S., Weirich, S., Kontermann, R. E., Rehm, M., & Fullstone, G. (2021). Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma. Molecules 2021, Vol. 26, Page 7582, 26(24), Article 24. https://doi.org/10.3390/MOLECULES26247582

Kontermann, R. E., Ungerechts, G., & Nettelbeck, D. M. (2021). Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics. mAbs, 13(1), Article 1. https://doi.org/10.1080/19420862.2021.1982447

Zhang, S., Liu, H., Yin, M., Pei, X., Hausser, A., Ishikawa, E., Yamasaki, S., & Jin, Z. G. (2020). Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice. Hepatology, hep.31176. https://doi.org/10.1002/hep.31176

Stöhr, D., Jeltsch, A., & Rehm, M. (2020). TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response. Int Rev Cell Mol Biol, 351, 57–99. https://doi.org/10.1016/bs.ircmb.2020.02.002

Wandrer, F., Liebig, S., Marhenke, S., Vogel, A., John, K., Manns, M. P., Teufel, A., Itzel, T., Longerich, T., Maier, O., Fischer, R., Kontermann, R. E., Pfizenmaier, K., Schulze-Osthoff, K., & Bantel, H. (2020). TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice. Cell Death Dis, 11(3), Article 3. https://doi.org/10.1038/s41419-020-2411-6

Fullstone, G., Bauer, T. L., Guttà, C., Salvucci, M., Prehn, J. H. M., & Rehm, M. (2020). The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell Death & Differentiation. https://doi.org/10.1038/s41418-020-0545-9

Imig, D., Pollak, N., Allgöwer, F., & Rehm, M. (2020). Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis. PLOS Computational Biology, 16(6), Article 6. https://doi.org/10.1371/journal.pcbi.1007812

Tansi, F. L., Rüger, R., Kollmeier, A. M., Rabenhold, M., Steiniger, F., Kontermann, R. E., Teichgräber, U. K., Fahr, A., & Hilger, I. (2020). Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes. Pharmaceutics, 12(4), Article 4. https://doi.org/10.3390/pharmaceutics12040370

Pegoretti, V., Swanson, K. A., Bethea, J. R., Probert, L., Eisel, U. L. M., & Fischer, R. (2020). Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity, 2020, 19. https://doi.org/10.1155/2020/7191080

Kuritz, K., Stöhr, D., Maichl, D. S., Pollak, N., Rehm, M., & Allgöwer, F. (2020). Reconstructing temporal and spatial dynamics from single-cell pseudotime using prior knowledge of real scale cell densities. Scientific Reports, 10(1), Article 1. https://doi.org/10.1038/s41598-020-60400-z

Fischer, R., Kontermann, R. E., & Pfizenmaier, K. (2020). Selective targeting of TNF receptors as a novel therapeutic approach. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.00401

Fabre, M., Ferrer, C., Dominguez-Hormaetxe, S., Bockorny, B., Murias, L., Seifert, O., Eisler, S. A., Kontermann, R. E., Pfizenmaier, K., Lee, S. Y., dM Vivanco, M., Lopez-Casas, P. P., Perea, S., Abbas, M., Richter, W., Simón, L., & Hidalgo, M. (2020). OMTX705, a Novel FAP-Targeting ADC demonstrates Activity in Chemotherapy and PD1-Resistant Solid Tumors Models. Clinical Cancer Research, clincanres.2238.2019. https://doi.org/10.1158/1078-0432.CCR-19-2238

Rau, A., Lieb, W. S., Seifert, O., Honer, J., Birnstock, D., Richter, F., Aschmoneit, N., Olayioye, M. A., & Kontermann, R. E. (2020). Inhibition of tumor cell growth and cancer stem cell expansion by a bispecific antibody targeting EGFR and HER3. Mol Cancer Ther. https://doi.org/10.1158/1535-7163.MCT-19-1095

Stöhr, D., Schmid, J. O., Beigl, T. B., Mack, A., Maichl, D. S., Cao, K., Budai, B., Fullstone, G., Kontermann, R. E., Mürdter, T. E., Tait, S. W. G., Hagenlocher, C., Pollak, N., Scheurich, P., & Rehm, M. (2020). Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death & Differentiation. https://doi.org/10.1038/s41418-020-0559-3

Hartung, F., Krüwel, T., Shi, X., Pfizenmaier, K., Kontermann, R., Chames, P., Alves, F., & Pardo, L. A. (2020). A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells. Front Pharmacol, 11, 686–686. https://doi.org/10.3389/fphar.2020.00686

Pacheco-Fernandez, N., Pakdel, M., Blank, B., Sanchez-Gonzalez, I., Weber, K., Tran, M. L., Hecht, T. K.-H., Gautsch, R., Beck, G., Perez, F., Hausser, A., Linder, S., & von Blume, J. (2020). Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. Journal of Cell Biology, 219(8), Article 8. https://doi.org/10.1083/jcb.201907058

Stöhr, D., & Rehm, M. (2020). Linking hyperosmotic stress and apoptotic sensitivity. The FEBS Journal, febs.15520. https://doi.org/10.1111/febs.15520

Sapski, S., Beha, N., Kontermann, R. E., & Müller, D. (2020). Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response. Cancer Immunol Immunother. https://doi.org/10.1007/s00262-020-02624-6

Müller, I., Strozyk, E., Schindler, S., Beissert, S., Oo, H. Z., Sauter, T., Lucarelli, P., Raeth, S., Hausser, A., Al Nakouzi, N., Fazli, L., Gleave, M. E., Liu, H., Simon, H.-U., Walczak, H., Green, D. R., Bartek, J., Daugaard, M., & Kulms, D. (2020). Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.12.023

Sánchez-González, I., Bobien, A., Molnar, C., Schmid, S., Strotbek, M., Boerries, M., Busch, H., & Olayioye, M. A. (2020). miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages. Cancer Research, canres.1934.2019. https://doi.org/10.1158/0008-5472.CAN-19-1934

Vetma, V., Guttà, C., Peters, N., Praetorius, C., Hutt, M., Seifert, O., Meier, F., Kontermann, R., Kulms, D., & Rehm, M. (2020). Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism. Cell Death & Differentiation 2020, 1--16. https://doi.org/10.1038/s41418-020-0512-5

Guttà, C., Rahman, A., Aura, C., Dynoodt, P., Charles, E. M., Hirschenhahn, E., Joseph, J., Wouters, J., de Chaumont, C., Rafferty, M., Warren, M., van den Oord, J. J., Gallagher, W. M., & Rehm, M. (2020). Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell Death & Disease, 11(2), Article 2. https://doi.org/10.1038/s41419-020-2309-3

White, K., Connor, K., Clerkin, J., Murphy, B. M., Salvucci, M., O’Farrell, A. C., Rehm, M., O’Brien, D., Prehn, J. H. M., Niclou, S. P., Lamfers, M. L. M., Verreault, M., Idbaih, A., Verhaak, R., Golebiewska, A., & Byrne, A. T. (2020). New hints towards a precision medicine strategy for IDH wild-type Glioblastoma. Annals of Oncology. https://doi.org/10.1016/j.annonc.2020.08.2336

Fullstone, G., Guttà, C., Beyer, A., & Rehm, M. (2020). The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling. npj Systems Biology and Applications, 6(1), Article 1. https://doi.org/10.1038/s41540-020-0128-x

Khawaja, H., Campbell, A., Roberts, J. Z., Javadi, A., O’Reilly, P., McArt, D., Allen, W. L., Majkut, J., Rehm, M., Bardelli, A., Di Nicolantonio, F., Scott, C. J., Kennedy, R., Vitale, N., Harrison, T., Sansom, O. J., Longley, D. B., Evergren, E., & Van Schaeybroeck, S. (2020). RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. Cell Death & Disease, 11(10), Article 10. https://doi.org/10.1038/s41419-020-03131-3

Noonan, J. J., Jarzabek, M., Lincoln, F. A., Cavanagh, B. L., Pariag, A. R., Juric, V., Young, L. S., Ligon, K. L., Jahns, H., Zheleva, D., Prehn, J. H. M., Rehm, M., Byrne, A. T., & Murphy, B. M. (2019). Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma. Cancers (Basel), 11(12), Article 12. https://doi.org/10.3390/cancers11122005

Tsur, N., Kogan, Y., Rehm, M., & Agur, Z. (2019). Response of Patients with Melanoma to Immune Checkpoint Blockade – Insights Gleaned from Analysis of a New Mathematical Mechanistic Model. Journal of Theoretical Biology, 110033. https://doi.org/10.1016/J.JTBI.2019.110033

Schrade, A., Bujotzek, A., Spick, C., Wagner, M., Goerl, J., Wezler, X., Georges, G., Kontermann, R. E., & Brinkmann, U. (2019). Back-To-Germline (B2G) Procedure for Antibody Devolution. Antibodies, 8(3), Article 3. https://doi.org/10.3390/antib8030045

Podder, B., Guttà, C., Rožanc, J., Gerlach, E., Feoktistova, M., Panayotova-Dimitrova, D., Alexopoulos, L. G., Leverkus, M., & Rehm, M. (2019). TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Cell Death & Differentiation, 1. https://doi.org/10.1038/s41418-019-0315-8

Fischer, R., Sendetski, M., Del Rivero, T., Martinez, G. F., Bracchi-Ricard, V., Swanson, K. A., Pruzinsky, E. K., Delguercio, N., Rosalino, M. J., Padutsch, T., Kontermann, R. E., Pfizenmaier, K., & Bethea, J. R. (2019). TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes. Proceedings of the National Academy of Sciences of the United States of America, 116(34), Article 34. https://doi.org/10.1073/pnas.1902091116

Beha, N., Harder, M., Ring, S., Kontermann, R. E., & Müller, D. (2019). IL-15-based trifunctional antibody-fusion proteins with costimulatory TNF-superfamily ligands in the single-chain format for cancer immunotherapy. Molecular Cancer Therapeutics, molcanther.1204.2018. https://doi.org/10.1158/1535-7163.MCT-18-1204

Fischer, R., Padutsch, T., Bracchi-Ricard, V., Murphy, K. L., Martinez, George. F., Delguercio, N., Elmer, N., Sendetski, M., Diem, R., Eisel, U. L. M., Smeyne, R. J., Kontermann, R. E., Pfizenmaier, K., & Bethea, J. R. (2019). Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2019.06.021

Noll, B., Benz, D., Frey, Y., Meyer, F., Lauinger, M., Eisler, S. A., Schmid, S., Hordijk, P. L., & Olayioye, M. A. (2019). DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes. Journal of cell science, jcs.223172. https://doi.org/10.1242/jcs.223172

Richter, F., Seifert, O., Herrmann, A., Pfizenmaier, K., & Kontermann, R. E. (2019). Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc. mAbs, 1--13. https://doi.org/10.1080/19420862.2019.1596512

Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Longley, D. B., Johnston, P. G., Lawler, M., Wilson, R., Salto-Tellez, M., Van Schaeybroeck, S., Rafferty, M., Gallagher, W. M., Rehm, M., & Prehn, J. H. M. (2019). A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic. JCO clinical cancer informatics, 3, Article 3. https://doi.org/10.1200/CCI.18.00056

Skoko, J., Rožanc, J., Charles, E. M., Alexopoulos, L. G., & Rehm, M. (2019). Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. BMC Cell Biology, 19(1), Article 1. https://doi.org/10.1186/s12860-018-0180-1

Padutsch, T., Maksim, S., Huber, C., Peters, N., Pfizenmaier, K., Bethea, J. R., Kontermann, R. E., & Fischer, R. (2019). Superior Treg-expanding properties of a novel dual-acting cytokine fusion protein. Frontiers in Pharmacology, 10, 1490. https://doi.org/10.3389/FPHAR.2019.01490

Seifert, O., Rau, A., Beha, N., Richter, F., & Kontermann, R. E. (2019). Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs, 19420862.2019.1603024. https://doi.org/10.1080/19420862.2019.1603024

von Blume, J., & Hausser, A. (2019). Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network. FEBS Letters, 1873--3468.13552. https://doi.org/10.1002/1873-3468.13552

Kleih, M., Böpple, K., Dong, M., Gaißler, A., Heine, S., Olayioye, M. A., Aulitzky, W. E., & Essmann, F. (2019). Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death & Disease, 10(11), Article 11. https://doi.org/10.1038/s41419-019-2081-4

Lieb, W. S., Lungu, C., Tamas, R., Berreth, H., Rathert, P., Storz, P., Olayioye, M. A., & Hausser, A. (2019). The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells. International Journal of Cancer, ijc.32798. https://doi.org/10.1002/ijc.32798

Olayioye, M. A., Noll, B., & Hausser, A. (2019). Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases. Cells, 8(12), Article 12. https://doi.org/10.3390/cells8121478

Puerto-Camacho, P., Amaral, A. T., Lamhamedi-Cherradi, S.-E., Menegaz, B. A., Castillo-Ecija, H., Ordóñez, J. L., Dominguez-Hormaetxe, S., Jordan-Perez, C., Diaz-Martin, J., Romero-Pérez, L., Lopez-Alvarez, M., Civantos-Jubera, G., Robles-Frias, M. J., Biscuola, M., Ferrer, C., Mora, J., Cuglievan, B., Schadler, K. L., Seifert, O., … de Álava, E. (2018). Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma. Clinical Cancer Research, clincanres.0936.2018. https://doi.org/10.1158/1078-0432.CCR-18-0936

Jensch, A., Frey, Y., Bitschar, K., Weber, P., Schmid, S., Hausser, A., Olayioye, M. A., & Radde, N. E. (2018). The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function. Journal of Biological Chemistry, jbc.RA118.003787. https://doi.org/10.1074/jbc.RA118.003787

Tansi, F. L., Rüger, R., Kollmeier, A. M., Rabenhold, M., Steiniger, F., Kontermann, R. E., Teichgraeber, U. K., Fahr, A., & Hilger, I. (2018). Endoglin based  in vivo  near-infrared fluorescence imaging of tumor models in mice using activatable liposomes. Biochimica et Biophysica Acta (BBA) - General Subjects. https://doi.org/10.1016/j.bbagen.2018.03.012

Siegemund, M., Schneider, F., Hutt, M., Seifert, O., Müller, I., Kulms, D., Pfizenmaier, K., & Kontermann, R. E. (2018). IgG-single-chain TRAIL fusion proteins for tumour therapy. Scientific Reports, 8(1), Article 1. https://doi.org/10.1038/s41598-018-24450-8

Hantusch, A., Das, K. K., García-Sáez, A. J., Brunner, T., & Rehm, M. (2018). Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance. Cell death & disease, 9(4), Article 4. https://doi.org/10.1038/s41419-018-0464-6

Carberry, S., D’Orsi, B., Monsefi, N., Salvucci, M., Bacon, O., Fay, J., Rehm, M., McNamara, D., Kay, E. W., & Prehn, J. M. H. (2018). The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Cell Death & Disease, 9(2), Article 2. https://doi.org/10.1038/s41419-017-0140-2

Rožanc, J., Sakellaropoulos, T., Antoranz, A., Guttà, C., Podder, B., Vetma, V., Rufo, N., Agostinis, P., Pliaka, V., Sauter, T., Kulms, D., Rehm, M., & Alexopoulos, L. (2018). Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death & Differentiation, 1. https://doi.org/10.1038/s41418-018-0210-8

Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., Luís, A., McCarthy, N., Montibeller, L., More, S., Papaioannou, A., Püschel, F., Sassano, M. L., Skoko, J., Agostinis, P., de Belleroche, J., Eriksson, L. A., Fulda, S., Gorman, A. M., … Samali, A. (2018). Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications. The FEBS Journal. https://doi.org/10.1111/febs.14608

Eisler, S. A., Curado, F., Link, G., Schulz, S., Noack, M., Steinke, M., Olayioye, M. A., & Hausser, A. (2018). A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions. eLife, 7. https://doi.org/10.7554/eLife.35907

Lincoln, F. A., Imig, D., Boccellato, C., Juric, V., Noonan, J., Kontermann, R. E., Allgöwer, F., Murphy, B. M., & Rehm, M. (2018). Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease, 9(11), Article 11. https://doi.org/10.1038/s41419-018-1160-2

Hantusch, A., Rehm, M., & Brunner, T. (2018). Counting on Death - Quantitative aspects of Bcl-2 family regulation. The FEBS Journal. https://doi.org/10.1111/febs.14516

Richter, F., Zettlitz, K. A., Seifert, O., Herrmann, A., Scheurich, P., Pfizenmaier, K., & Kontermann, R. E. (2018). Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity. mAbs, 19420862.2018.1524664. https://doi.org/10.1080/19420862.2018.1524664

Crawford, N., Salvucci, M., Hellwig, C. T., Lincoln, F. A., Mooney, R. E., O’Connor, C. L., Prehn, J. H., Longley, D. B., & Rehm, M. (2018). Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711. Cell Death & Differentiation. https://doi.org/10.1038/s41418-018-0082-y

Fischer, R., Proske, M., Duffey, M., Stangl, H., Martinez, G. F., Peters, N., Kraske, A., Straub, R. H., Bethea, J. R., Kontermann, R. E., & Pfizenmaier, K. (2018). Selective activation of tumor necrosis factor receptor 2 induces anti-inflammatory responses and alleviates experimental arthritis. Arthritis & Rheumatology. https://doi.org/10.1002/art.40413

Satta, A., Mezzanzanica, D., Caroli, F., Frigerio, B., Nicola, M. D., Kontermann, R. E., Iacovelli, F., Desideri, A., Anichini, A., Canevari, S., Gianni, A. M., & Figini, M. (2018). Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells. mAbs, 19420862.2018.1494105. https://doi.org/10.1080/19420862.2018.1494105

Williams, S. K., Fairless, R., Maier, O., Liermann, P. C., Pichi, K., Fischer, R., Eisel, U. L. M., Kontermann, R., Herrmann, A., Weksler, B., Romero, N., Couraud, P.-O., Pfizenmaier, K., & Diem, R. (2018). Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports, 8(1), Article 1. https://doi.org/10.1038/s41598-018-31957-7

Apweiler, R., Beissbarth, T., Berthold, M. R., Blüthgen, N., Burmeister, Y., Dammann, O., Deutsch, A., Feuerhake, F., Franke, A., Hasenauer, J., Hoffmann, S., Höfer, T., Jansen, P. L., Kaderali, L., Klingmüller, U., Koch, I., Kohlbacher, O., Kuepfer, L., Lammert, F., … Wolkenhauer, O. (2018). Whither systems medicine? Experimental &Amp; Molecular Medicine, 50, e453--. http://dx.doi.org/10.1038/emm.2017.290

Danish, L., Imig, D., Allgöwer, F., Scheurich, P., & Pollak, N. (2018). Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLOS ONE, 13(6), Article 6. https://doi.org/10.1371/journal.pone.0198203

Fellermeier-Kopf, S., Gieseke, F., Sahin, U., Müller, D., Pfizenmaier, K., & Kontermann, R. E. (2018). Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans. OncoImmunology, 7(9), Article 9. https://doi.org/10.1080/2162402X.2018.1471442

Hutt, M., Fellermeier-Kopf, S., Seifert, O., Schmitt, L. C., Pfizenmaier, K., & Kontermann, R. E. (2018). Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells. Oncotarget, 9(13), Article 13. https://doi.org/10.18632/oncotarget.24379

Del Mistro, G., Lucarelli, P., Müller, I., De Landtsheer, S., Zinoveva, A., Hutt, M., Siegemund, M., Kontermann, R. E., Beissert, S., Sauter, T., & Kulms, D. (2018). Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. npj Systems Biology and Applications, 4(1), Article 1. https://doi.org/10.1038/s41540-018-0075-y

Chen, M., Urs, M. J., Sánchez-González, I., Olayioye, M. A., Herde, M., & Witte, C.-P. (2018). m6A RNA Degradation Products are Catabolized by an Evolutionarily Conserved N6-methyl-AMP Deaminase in Plant and Mammalian Cells. The Plant cell, tpc.00236.2018. https://doi.org/10.1105/tpc.18.00236

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., … Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation. https://doi.org/10.1038/s41418-017-0012-4

Schmitt, L. C., Rau, A., Seifert, O., Honer, J., Hutt, M., Schmid, S., Zantow, J., Hust, M., Dübel, S., Olayioye, M. A., & Kontermann, R. E. (2017). Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV. mAbs, 9(5), Article 5. https://doi.org/10.1080/19420862.2017.1319023

Kuritz, K., Stöhr, D., Pollak, N., & Allgöwer, F. (2017). On the relationship between cell cycle analysis with ergodic principles and age-structured cell population models. Journal of Theoretical Biology, 414, 91--102. https://doi.org/10.1016/j.jtbi.2016.11.024

Schröder, P., Wagner, A., Stöhr, D., Rehm, M., & Ehlers, W. (2017). Data-driven simulation of metastatic processes within brain tissue. PAMM, 17(1), Article 1. https://doi.org/10.1002/pamm.201710080

Lakner, P. H., Monaghan, M. G., Möller, Y., Olayioye, M. A., & Schenke-Layland, K. (2017). Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models. Scientific Reports, 7, 42730. https://doi.org/10.1038/srep42730

Pieper, L. A., Strotbek, M., Wenger, T., Gamer, M., Olayioye, M. A., & Hausser, A. (2017). Secretory pathway optimization of CHO producer cells by co-engineering of the mitosRNA-1978 target genes CerS2 and Tbc1D20. Metabolic Engineering, 40, 69--79. https://doi.org/10.1016/j.ymben.2017.01.003

Hantusch, A., Brunner, T., Frickey, T., & Rehm, M. (2017). Bcl-2-Ome-a database and interactive web service for dissecting the Bcl-2 interactome. Cell Death and Differentiation, 24(1), Article 1. https://doi.org/10.1038/cdd.2016.129

Vetma, V., Rozanc, J., Charles, E. M., Hellwig, C. T., Alexopoulos, L. G., & Rehm, M. (2017). Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 25(9), Article 9. https://doi.org/10.3727/096504017x14897145996933

Sapski, S., Beha, N., Kontermann, R., & Müller, D. (2017). Tumor-targeted costimulation with antibody-fusion proteins improves bispecific antibody-mediated immune response in presence of immunosuppressive factors. OncoImmunology, 6(12), Article 12. https://doi.org/10.1080/2162402X.2017.1361594

Hausser, A., & Schlett, K. (2017). Coordination of AMPA receptor trafficking by Rab GTPases. Small GTPases, 1--14. https://doi.org/10.1080/21541248.2017.1337546

Capasso, S., Sticco, L., Rizzo, R., Pirozzi, M., Russo, D., Dathan, N. A., Campelo, F., van Galen, J., Hölttä‐Vuori, M., Turacchio, G., Hausser, A., Malhotra, V., Riezman, I., Riezman, H., Ikonen, E., Luberto, C., Parashuraman, S., Luini, A., & D’Angelo, G. (2017). Sphingolipid metabolic flow controls phosphoinositide turnover at the \textlessi\textgreatertrans\textless/i\textgreater ‐Golgi network. The EMBO Journal, 36(12), Article 12. https://doi.org/10.15252/embj.201696048

Fischer, R., Marsal, J., Guttà, C., Eisler, S. A., Peters, N., Bethea, J. R., Pfizenmaier, K., & Kontermann, R. E. (2017). Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2. Scientific Reports, 7(1), Article 1. https://doi.org/10.1038/s41598-017-06993-4

Salvucci, M., Urstle, M. L., Morgan, C., Curry, S., Cremona, M., Lindner, A. U., Bacon, O., Resler, A. J., Murphy, A. C., O’Byrne, R., Flanagan, L., Dasgupta, S., Rice, N., Pilati, C., Zink, E., Scholler, L. M., Toomey, S., Lawler, M., Johnston, P. G., … Prehn, J. H. M. (2017). A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer. Clinical Cancer Research, 23(5), Article 5. https://doi.org/10.1158/1078-0432.CCR-16-1084

Strotbek, M., Schmid, S., Sánchez-González, I., Boerries, M., Busch, H., & Olayioye, M. A. (2017). miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. International Journal of Cancer, 140(10), Article 10. https://doi.org/10.1002/ijc.30661

Hutt, M., Marquardt, L., Seifert, O., Siegemund, M., Müller, I., Kulms, D., Pfizenmaier, K., & Kontermann, R. E. (2017). Superior properties of Fc-comprising scTRAIL fusion proteins. Molecular Cancer Therapeutics, 16(12), Article 12. https://doi.org/10.1158/1535-7163.MCT-17-0551

Brinkmann, U., & Kontermann, R. E. (2017). The making of bispecific antibodies. mAbs, 9(2), Article 2. https://doi.org/10.1080/19420862.2016.1268307

Pieper, L. A., Strotbek, M., Wenger, T., Olayioye, M. A., & Hausser, A. (2017). ATF6β-based fine-tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells. Biotechnology and Bioengineering, 114(6), Article 6. https://doi.org/10.1002/bit.26263

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Szíber, Z., Liliom, H., Morales, C. O. O., Ignácz, A., Rátkai, A. E., Ellwanger, K., Link, G., Szűcs, A., Hausser, A., & Schlett, K. (2016). Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover. Molecular biology of the cell, 28(2), Article 2. https://doi.org/10.1091/mbc.E16-07-0526

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Möller, Y., Morkel, M., Schmid, J., Beyes, S., Hendrick, J., Strotbek, M., Riemer, P., Schmid, S., Schmitt, L. C., Kontermann, R., Mürdter, T., Schwab, M., Sers, C., & Olayioye, M. a. (2016). Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling. Oncotarget, 7(33), Article 33. https://doi.org/10.18632/oncotarget.10658

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Kälble, F., Damaske, J., Heide, D., Arnold, I., Richter, F., Maier, O., Eisel, U., Scheurich, P., Pfizenmaier, K., Zeier, M., Schwenger, V., & Ranzinger, J. (2016). Selective blocking of TNF receptor 1 attenuates peritoneal dialysis fluid induced inflammation of the peritoneum in mice. PLoS ONE, 11(10), Article 10. https://doi.org/10.1371/journal.pone.0163314

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Hendrick, J., Franz-Wachtel, M., Moeller, Y., Schmid, S., Macek, B., & Olayioye, M. A. (2016). The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling. Journal of Cell Science, 129(19), Article 19. https://doi.org/10.1242/jcs.190074

Tansi, F. L., Rüger, R., Böhm, C., Kontermann, R. E., Teichgraeber, U. K., Fahr, A., & Hilger, I. (2016). Potential of activatable FAP-targeting immunoliposomes in intraoperative imaging of spontaneous metastases. Biomaterials, 88, 70--82. https://doi.org/10.1016/j.biomaterials.2016.02.028

Hendrick, J., & Olayioye, M. A. (2016). Spatial Rho regulation: Molecular mechanisms controlling the GAP protein DLC3. Small GTPases, 1--7. https://doi.org/10.1080/21541248.2016.1260673

Fellermeier, S., Beha, N., Meyer, J. E., Ring, S., Bader, S., Kontermann, R. E., & Müller, D. (2016). Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format. OncoImmunology, 5(11), Article 11. https://doi.org/10.1080/2162402X.2016.1238540

Fernández-Ulibarri, I., Hammer, K., Arndt, M. A. E., Kaufmann, J. K., Dorer, D., Engelhardt, S., Kontermann, R. E., Hess, J., Allgayer, H., Krauss, J., & Nettelbeck, D. M. (2015). Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. International Journal of Cancer, 136(9), Article 9. https://doi.org/10.1002/ijc.29258

Weber, P., Hornjik, M., Olayioye, M. A., Hausser, A., & Radde, N. E. (2015). A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Systems Biology, 9(1), Article 1. https://doi.org/10.1186/s12918-015-0147-1

Kang, B., Okwieka, P., Schöttler, S., Seifert, O., Kontermann, R. E., Pfizenmaier, K., Musyanovych, A., Meyer, R., Diken, M., Sahin, U., Mailänder, V., Wurm, F. R., & Landfester, K. (2015). Tailoring the stealth properties of biocompatible polysaccharide nanocontainers. Biomaterials, 49, 125--134. https://doi.org/10.1016/j.biomaterials.2015.01.042

Fischer, R., Kontermann, R., & Maier, O. (2015). Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy. Antibodies, 4(1), Article 1. https://doi.org/10.3390/antib4010048

Schuster, L., Seifert, O., Vollmer, S., Kontermann, R. E., Schlosshauer, B., & Hartmann, H. (2015). Immunoliposomes for Targeted Delivery of an Antifibrotic Drug. Molecular Pharmaceutics, 12(9), Article 9. https://doi.org/10.1021/acs.molpharmaceut.5b00012

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Wortzel, I., Hanoch, T., Porat, Z., Hausser, A., & Seger, R. (2015). Mitotic Golgi translocation of ERK1c is mediated by PI4KIIIβ/14-3-3γ shuttling complex. Journal of cell science, 204(22), Article 22. https://doi.org/10.1242/jcs.170910

Herr, R., Köhler, M., Andrlová, H., Weinberg, F., Möller, Y., Halbach, S., Lutz, L., Mastroianni, J., Klose, M., Bittermann, N., Kowar, S., Zeiser, R., Olayioye, M. A., Lassmann, S., Busch, H., Boerries, M., & Brummer, T. (2015). B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Research, 75(1), Article 1. https://doi.org/10.1158/0008-5472.CAN-13-3686

Braun, A. C., Hendrick, J., Eisler, S. A., Schmid, S., Hausser, A., & Olayioye, M. A. (2015). The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking. Journal of Cell Science, 128(7), Article 7. https://doi.org/10.1242/jcs.163857

Müller, D. (2015). Antibody fusions with immunomodulatory proteins for cancer therapy. Pharmacology and Therapeutics, 154, 57--66. https://doi.org/10.1016/j.pharmthera.2015.07.001

Braun, A. C., & Olayioye, M. A. (2015). Rho regulation: DLC proteins in space and time. Cellular Signalling, 27(8), Article 8. https://doi.org/10.1016/j.cellsig.2015.04.003

Rabenhold, M., Steiniger, F., Fahr, A., Kontermann, R. E., & Rüger, R. (2015). Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. Journal of Controlled Release, 201, 56--67. https://doi.org/10.1016/j.jconrel.2015.01.022

Unverdorben, F., Hutt, M., Seifert, O., & Kontermann, R. E. (2015). A fab-selective immunoglobulin-binding domain from streptococcal protein G with improved half-life extension properties. PLoS ONE, 10(10), Article 10. https://doi.org/10.1371/journal.pone.0139838

Bencsik, N., Szíber, Z., Liliom, H., Tárnok, K., Borbély, S., Gulyás, M., Rátkai, A., Szucs, A., Hazai-Novák, D., Ellwanger, K., Rácz, B., Pfizenmaier, K., Hausser, A., & Schlett, K. (2015). Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation. Journal of Cell Biology, 210(5), Article 5. https://doi.org/10.1083/jcb.201501114

Tárnok, K., Gulyás, M., Bencsik, N., Ferenc, K., Pfizenmaier, K., Hausser, A., & Schlett, K. (2015). A new tool for the quantitative analysis of dendritic filopodial motility. Cytometry Part A, 87(1), Article 1. https://doi.org/10.1002/cyto.a.22569

Kontermann, R. E., & Brinkmann, U. (2015). Bispecific antibodies. Drug Discovery Today, 20(7), Article 7. https://doi.org/10.1016/j.drudis.2015.02.008

Kiesgen, S., Liebers, N., Cremer, M., Arnold, U., Weber, T., Keller, A., Herold-Mende, C., Dyckhoff, G., Jäger, D., Kontermann, R. E., Arndt, M. A. E., Krauss, J., & Wu, A. (2014). A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor. Protein Engineering, Design and Selection, 27(10), Article 10. https://doi.org/10.1093/protein/gzu040

Raeth, S., Sacchetti, B., Siegel, G., Mau-Holzmann, U. a, Hansmann, J., Vacun, G., Hauk, T. G., Pfizenmaier, K., & Hausser, A. (2014). A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. Stem cells and development, 23(10), Article 10. https://doi.org/10.1089/scd.2013.0367

Moosmann, A., Müller, E., & Böttinger, H. (2014). Purification of PEGylated Proteins, with the example of PEGylated lysozyme and PEGylated scFv. Methods in Molecular Biology, 1129, 527--538. https://doi.org/10.1007/978-1-62703-977-2_37

Kermer, V., Hornig, N., Harder, M., Bondarieva, A., Kontermann, R. E., & Muller, D. (2014). Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy. Molecular Cancer Therapeutics, 13(1), Article 1. https://doi.org/10.1158/1535-7163.MCT-13-0282

Oesterreich, B., Lorenz, B., Schmitter, T., Kontermann, R., Zenn, M., Zimmermann, B., Haake, M., Lorenz, U., & Ohlsen, K. (2014). Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, ahumanized monoclonal antibody as substantial component for an immunotherapeutic approach. Human Vaccines and Immunotherapeutics, 10(4), Article 4. https://doi.org/10.4161/hv.27692

Konrath, F., Witt, J., Sauter, T., & Kulms, D. (2014). Identification of New IκBα Complexes by an Iterative Experimental and Mathematical Modeling Approach. PLoS Computational Biology, 10(3), Article 3. https://doi.org/10.1371/journal.pcbi.1003528

Seifert, O., Plappert, A., Fellermeier, S., Siegemund, M., Pfizenmaier, K., & Kontermann, R. E. (2014). Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties. Molecular Cancer Therapeutics, 13(1), Article 1. https://doi.org/10.1158/1535-7163.MCT-13-0396

Fischer, R., Wajant, H., Kontermann, R., Pfizenmaier, K., & Maier, O. (2014). Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia, 62(2), Article 2. https://doi.org/10.1002/glia.22605

Siegemund, M., Richter, F., Seifert, O., Unverdorben, F., & Kontermann, R. E. (2014). Expression and Purification of Recombinant Antibody Formats and Antibody Fusion Proteins. In Methods in molecular biology (Clifton, N.J.) (Bd. 1131, S. 273--295). https://doi.org/10.1007/978-1-62703-992-5_18

Williams, S. K., Maier, O., Fischer, R., Fairless, R., Hochmeister, S., Stojic, A., Pick, L., Haar, D., Musiol, S., Storch, M. K., Pfizenmaier, K., & Diem, R. (2014). Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis. PLoS ONE, 9(2), Article 2. https://doi.org/10.1371/journal.pone.0090117

Weidle, U. H., Kontermann, R. E., & Brinkmann, U. (2014). Tumor-antigen-binding bispecific antibodies for cancer treatment. Seminars in Oncology, 41(5), Article 5. https://doi.org/10.1053/j.seminoncol.2014.08.004

Bischoff, A., Huck, B., Keller, B., Strotbek, M., Schmid, S., Boerries, M., Busch, H., Müller, D., & Olayioye, M. A. (2014). MiR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion. Cancer Research, 74(18), Article 18. https://doi.org/10.1158/0008-5472.CAN-13-3319

Seifert, O., Pollak, N., Nusser, A., Steiniger, F., Rüger, R., Pfizenmaier, K., & Kontermann, R. E. (2014). Immuno-LipoTRAIL: Targeted delivery of TRAIL-functionalized liposomal nanoparticles. Bioconjugate Chemistry, 25(5), Article 5. https://doi.org/10.1021/bc400517j

Huck, B., Duss, S., Hausser, A., & Olayioye, M. A. (2014). Elevated protein kinase D3 (PKD3) expression supports proliferation of Triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. Journal of Biological Chemistry, 289(6), Article 6. https://doi.org/10.1074/jbc.M113.502633

Neumann, S., Hasenauer, J., Pollak, N., & Scheurich, P. (2014). Dominant negative effects of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by Formation of heteromeric complexes. Journal of Biological Chemistry, 289(23), Article 23. https://doi.org/10.1074/jbc.M114.559468

Lindner, R., Moosmann, A., Dietrich, A., Böttinger, H., Kontermann, R., & Siemann-Herzberg, M. (2014). Process development of periplasmatically produced single chain fragment variable against epidermal growth factor receptor in Escherichia coli. Journal of Biotechnology, 192, 136--145. https://doi.org/10.1016/j.jbiotec.2014.10.003

Diebolder, P., Keller, A., Haase, S., Schlegelmilch, A., Kiefer, J. D., Karimi, T., Weber, T., Moldenhauer, G., Kehm, R., Eis-Hübinger, A. M., Jäger, D., Federspil, P. A., Herold-Mende, C., Dyckhoff, G., Kontermann, R. E., Arndt, M. A., & Krauss, J. (2014). Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potential. mAbs, 6(1), Article 1. https://doi.org/10.4161/mabs.27236

Möller, Y., Siegemund, M., Beyes, S., Herr, R., Lecis, D., Delia, D., Kontermann, R., Brummer, T., Pfizenmaier, K., & Olayioye, M. A. (2014). EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. PLoS ONE, 9(9), Article 9. https://doi.org/10.1371/journal.pone.0107165

Barras, D., Chevalier, N., Zoete, V., Dempsey, R., Lapouge, K., Olayioye, M. A., Michielin, O., & Widmann, C. (2014). A WXW Motif Is Required for the Anticancer Activity of the TAT-RasGAP317–326 Peptide. Journal of Biological Chemistry, 289(34), Article 34. https://doi.org/10.1074/jbc.M114.576272

Wille, C., Köhler, C., Armacki, M., Jamali, A., Gössele, U., Pfizenmaier, K., Seufferlein, T., & Eiseler, T. (2014). Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases. Molecular biology of the cell, 25(3), Article 3. https://doi.org/10.1091/mbc.E13-06-0334

Rüger, R., Tansi, F. L., Rabenhold, M., Steiniger, F., Kontermann, R. E., Fahr, A., & Hilger, I. (2014). In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes. Journal of Controlled Release, 186, 1--10. https://doi.org/10.1016/j.jconrel.2014.04.050

Jaiswal, M., Dvorsky, R., Amin, E., Risse, S. L., Fansa, E. K., Zhang, S. C., Taha, M. S., Gauhar, A. R., Nakhaei-Rad, S., Kordes, C., Koessmeier, K. T., Cirstea, I. C., Olayioye, M. A., Häussinger, D., & Ahmadian, M. R. (2014). Functional cross-talk between ras and rho pathways: A ras-specific gtpase-activating protein (p120RasGAP) competitively inhibits the rhogap activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, 289(10), Article 10. https://doi.org/10.1074/jbc.M113.527655

Kakarla, S., Chow, K. K. H., Mata, M., Shaffer, D. R., Song, X. T., Wu, M. F., Liu, H., Wang, L. L., Rowley, D. R., Pfizenmaier, K., & Gottschalk, S. (2013). Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Molecular Therapy, 21(8), Article 8. https://doi.org/10.1038/mt.2013.110

Strotbek, M., Florin, L., Koenitzer, J., Tolstrup, A., Kaufmann, H., Hausser, A., & Olayioye, M. A. (2013). Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells. Metabolic Engineering, 20, 157--166. https://doi.org/10.1016/j.ymben.2013.10.005

Hornig, N., Reinhardt, K., Kermer, V., Kontermann, R. E., & Müller, D. (2013). Evaluating combinations of costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy. Cancer Immunology, Immunotherapy, 62(8), Article 8. https://doi.org/10.1007/s00262-013-1441-7

Wahl, K., Siegemund, M., Lehner, F., Vondran, F., Nüssler, A., Länger, F., Krech, T., Kontermann, R., Manns, M. P., Schulze-Osthoff, K., Pfizenmaier, K., & Bantel, H. (2013). Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology, 57(2), Article 2. https://doi.org/10.1002/hep.26082

Berger, V., Richter, F., Zettlitz, K., Unverdorben, F., Scheurich, P., Herrmann, A., Pfizenmaier, K., & Kontermann, R. E. (2013). An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action. Protein Engineering, Design and Selection, 26(10), Article 10. https://doi.org/10.1093/protein/gzt044

Ellwanger, K., & Hausser, A. (2013). Physiological functions of protein kinase D in vivo. IUBMB Life, 65(2), Article 2. https://doi.org/10.1002/iub.1116

Vörsmann, H., Groeber, F., Walles, H., Busch, S., Beissert, S., Walczak, H., & Kulms, D. (2013). Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing. Cell Death and Disease, 4(7), Article 7. https://doi.org/10.1038/cddis.2013.249

Kienzle, C., Eisler, S. A., Villeneuve, J., Brummer, T., Olayioye, M. A., & Hausser, A. (2013). PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Molecular Biology of the Cell, 24(3), Article 3. https://doi.org/10.1091/mbc.E12-03-0198

Wajant, H., Gerspach, J., & Pfizenmaier, K. (2013). Engineering death receptor ligands for cancer therapy. Cancer Letters, 332(2), Article 2. https://doi.org/10.1016/j.canlet.2010.12.019

Olayioye, M. A., Barisic, S., & Hausser, A. (2013). Multi-level control of actin dynamics by protein kinase D. Cellular Signalling, 25(9), Article 9. https://doi.org/10.1016/j.cellsig.2013.04.010

Maier, O., Fischer, R., Agresti, C., & Pfizenmaier, K. (2013). TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. Biochemical and Biophysical Research Communications, 440(2), Article 2. https://doi.org/10.1016/j.bbrc.2013.09.083

Richter, F., Liebig, T., Guenzi, E., Herrmann, A., Scheurich, P., Pfizenmaier, K., & Kontermann, R. E. (2013). Antagonistic TNF receptor one-specific antibody (ATROSAB): Receptor binding and in vitro bioactivity. PLoS ONE, 8(8), Article 8. https://doi.org/10.1371/journal.pone.0072156

Lopez-Ramirez, M. A., Fischer, R., Torres-Badillo, C. C., Davies, H. A., Logan, K., Pfizenmaier, K., Male, D. K., Sharrack, B., & Romero, I. A. (2012). Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells. The Journal of Immunology, 189(6), Article 6. https://doi.org/10.4049/jimmunol.1103460

Olayioye, M. A., & Hausser, A. (2012). Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1821(8), Article 8. https://doi.org/10.1016/j.bbalip.2011.12.005

Witt, J., Konrath, F., Sawodny, O., Ederer, M., Kulms, D., & Sauter, T. (2012). Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-κB signalling using a minimal mathematical model. PLoS ONE, 7(7), Article 7. https://doi.org/10.1371/journal.pone.0040274

Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes. Antibodies, 1(3), Article 3. https://doi.org/10.3390/antib1020199

Eisler, S. A., Fuchs, Y. F., Pfizenmaier, K., & Hausser, A. (2012). G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-network. Biotechnology Journal, 7(1), Article 1. https://doi.org/10.1002/biot.201100273

Seifert, O., Plappert, A., Heidel, N., Fellermeier, S., Messerschmidt, S. K. E., Richter, F., & Kontermann, R. E. (2012). The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity. Protein Engineering, Design and Selection, 25(10), Article 10. https://doi.org/10.1093/protein/gzs059

Siegemund, M., Pollak, N., Seifert, O., Wahl, K., Hanak, K., Vogel, A., Nussler, A. K., Göttsch, D., Münkel, S., Bantel, H., Kontermann, R. E., & Pfizenmaier, K. (2012). Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. Cell Death and Disease, 3(4), Article 4. https://doi.org/10.1038/cddis.2012.29

Kontermann, R. E. (2012). Dual targeting strategies with bispecific antibodies. mAbs, 4(2), Article 2. https://doi.org/10.4161/mabs.4.2.19000

Kermer, V., Baum, V., Hornig, N., Kontermann, R. E., & Müller, D. (2012). An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 \textlessi\textgreatertrans\textless/i\textgreater -Presentation at the Tumor Site. Molecular Cancer Therapeutics, 11(6), Article 6. https://doi.org/10.1158/1535-7163.MCT-12-0019

Unverdorben, F., Färber-Schwarz, A., Richter, F., Hutt, M., & Kontermann, R. E. (2012). Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A. Protein Engineering, Design and Selection, 25(2), Article 2. https://doi.org/10.1093/protein/gzr061

Kempkes, C., Rattenholl, A., Buddenkotte, J., Strozyk, E., Eberle, J., Hausser, A., Cevikbas, F., Schneider, S. W., & Steinhoff, M. (2012). Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1. Journal of Investigative Dermatology, 132(2), Article 2. https://doi.org/10.1038/jid.2011.314

Hasenauer, J., Heinrich, J., Doszczak, M., Scheurich, P., Weiskopf, D., & Allgöwer, F. (2012). A visual analytics approach for models of heterogeneous cell populations. Eurasip Journal on Bioinformatics and Systems Biology, 2012(1), Article 1. https://doi.org/10.1186/1687-4153-2012-4

Holeiter, G., Bischoff, A., Braun, A. C., Huck, B., Erlmann, P., Schmid, S., Herr, R., Brummer, T., & Olayioye, M. A. (2012). The RhoGAP protein deleted in liver cancer 3 (DLC3) is essential for adherens junctions integrity. Oncogenesis, 1(6), Article 6. https://doi.org/10.1038/oncsis.2012.13

Heering, J., Weis, N., Holeiter, M., Neugart, F., Staebler, A., Fehm, T. N., Bischoff, A., Schiller, J., Duss, S., Schmid, S., Korte, T., Herrmann, A., & Olayioye, M. A. (2012). Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. Cancer Research, 72(11), Article 11. https://doi.org/10.1158/0008-5472.CAN-11-3069

Moosmann, A., Gerlach, E., Lindner, R., & Böttinger, H. (2012). Purification of a PEGylated single chain Fv. Journal of Chromatography A, 1236, 90--96. https://doi.org/10.1016/j.chroma.2012.03.004

Franz-Wachtel, M., Eisler, S. A., Krug, K., Wahl, S., Carpy, A., Nordheim, A., Pfizenmaier, K., Hausser, A., & Macek, B. (2012). Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells. Molecular & Cellular Proteomics, 11(5), Article 5. https://doi.org/10.1074/mcp.M111.016014

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Müller, D. (2012). Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15. OncoImmunology, 1(7), Article 7. https://doi.org/10.4161/onci.20824

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Kontermann, R. E. (2012). Antibody-cytokine fusion proteins. Archives of Biochemistry and Biophysics, 526(2), Article 2. https://doi.org/10.1016/j.abb.2012.03.001

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Gerspach, J., Schneider, B., Müller, N., Otz, T., Wajant, H., & Pfizenmaier, K. (2011). Genetic engineering of death ligands for improvement of therapeutic activity. Advances in Experimental Medicine and Biology, 691, 507--519. https://doi.org/10.1007/978-1-4419-6612-4_53

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Gehrmann, M., Doß, B. T., Wagner, M., Zettlitz, K. A., Kontermann, R. E., Foulds, G., Pockley, A. G., & Multhoff, G. (2011). A novel expression and purification system for the production of enzymatic and biologically active human granzyme B. Journal of Immunological Methods, 371(1–2), Article 1–2. https://doi.org/10.1016/j.jim.2011.06.007

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Ellwanger, K., Kienzle, C., Lutz, S., Jin, Z., Wiekowski, M. T., Pfizenmaier, K., & Hausser, A. (2011). Protein kinase D controls voluntary-running-induced skeletal muscle remodelling. Biochemical Journal, 440(3), Article 3. https://doi.org/10.1042/BJ20101980

Hörnle, M., Peters, N., Thayaparasingham, B., Vörsmann, H., Kashkar, H., & Kulms, D. (2011). Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene, 30(5), Article 5. https://doi.org/10.1038/onc.2010.434

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Rothdiener, M., Müller, D., Castro, P. G., Scholz, A., Schwemmlein, M., Fey, G., Heidenreich, O., & Kontermann, R. E. (2010). Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems. Journal of Controlled Release, 144(2), Article 2. https://doi.org/10.1016/j.jconrel.2010.02.020

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Hopp, J., Hornig, N., Zettlitz, K. A., Schwarz, A., Fuß, N., Müller, D., & Kontermann, R. E. (2010). The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Engineering, Design and Selection, 23(11), Article 11. https://doi.org/10.1093/protein/gzq058

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Czöndör, K., Ellwanger, K., Fuchs, Y. F., Lutz, S., Gulyás, M., Mansuy, I. M., Hausser, A., Pfizenmaier, K., & Schlett, K. (2009). Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Molecular biology of the cell, 20(7), Article 7. https://doi.org/10.1091/mbc.E08-09-0957

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Gerspach, J., Pfizenmaier, K., & Wajant, H. (2009). Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. BioFactors, 35(4), Article 4. https://doi.org/10.1002/biof.50

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Ahmadvand, D., Rasaee, M. J., Rahbarizadeh, F., Kontermann, R. E., & Sheikholislami, F. (2009). Cell selection and characterization of a novel human endothelial cell specific nanobody. Molecular Immunology, 46(8–9), Article 8–9. https://doi.org/10.1016/j.molimm.2009.01.021

Kontermann, R. E. (2009). Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs, 23(2), Article 2. https://doi.org/10.2165/00063030-200923020-00003

Stork, R., Campigna, E., Robert, B., Müller, D., & Kontermann, R. E. (2009). Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. Journal of Biological Chemistry, 284(38), Article 38. https://doi.org/10.1074/jbc.M109.027078

Messerschmidt, S. K. E., Musyanovych, A., Altvater, M., Scheurich, P., Pfizenmaier, K., Landfester, K., & Kontermann, R. E. (2009). Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells. Journal of Controlled Release, 137(1), Article 1. https://doi.org/10.1016/j.jconrel.2009.03.010

Heering, J., Erlmann, P., & Olayioye, M. A. (2009). Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. Experimental Cell Research, 315(15), Article 15. https://doi.org/10.1016/j.yexcr.2009.05.022

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Fuchs, Y. F., Eisler, S. A., Link, G., Schlicker, O., Bunt, G., Pfizenmaier, K., & Hausser, A. (2009). A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal. Traffic, 10(7), Article 7. https://doi.org/10.1111/j.1600-0854.2009.00918.x

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Wyzgol, A., Muller, N., Fick, A., Munkel, S., Grigoleit, G. U., Pfizenmaier, K., & Wajant, H. (2009). Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand. The Journal of Immunology, 183(3), Article 3. https://doi.org/10.4049/jimmunol.0802597

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Beuttler, J., Rothdiener, M., Müller, D., Frejd, F. Y., & Kontermann, R. E. (2009). Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL). Bioconjugate Chemistry, 20(6), Article 6. https://doi.org/10.1021/bc900061v

Florin, L., Pegel, A., Becker, E., Hausser, A., Olayioye, M. A., & Kaufmann, H. (2009). Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. Journal of Biotechnology, 141(1–2), Article 1–2. https://doi.org/10.1016/j.jbiotec.2009.02.014

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Erlmann, P., Schmid, S., Horenkamp, F. A., Geyer, M., Pomorski, T. G., & Olayioye, M. A. (2009). DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain. Molecular biology of the cell, 20(20), Article 20. https://doi.org/10.1091/mbc.E09-03-0247

Peterburs, P., Heering, J., Link, G., Pfizenmaier, K., Olayioye, M. A., & Hausser, A. (2009). Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Research, 69(14), Article 14. https://doi.org/10.1158/0008-5472.CAN-09-0718

Messerschmidt, S. K. E., Kolbe, A., Müller, D., Knoll, M., Pleiss, J., & Kontermann, R. E. (2008). Novel single-chain Fv′ formats for the generation of immunoliposomes by site-directed coupling. Bioconjugate Chemistry, 19(1), Article 1. https://doi.org/10.1021/bc700349k

Barisic, S., Strozyk, E., Peters, N., Walczak, H., & Kulms, D. (2008). Identification of PP2A as a crucial regulator of the NF-$\kappa$B feedback loop: Its inhibition by UVB turns NF-κB into a pro-apoptotic factor. Cell Death and Differentiation, 15(11), Article 11. https://doi.org/10.1038/cdd.2008.98

Müller, D., Frey, K., & Kontermann, R. E. (2008). A novel antibody-4-1BBL fusion protein for targeted costimulation in cancer immunotherapy. Journal of Immunotherapy, 31(8), Article 8. https://doi.org/10.1097/CJI.0b013e31818353e9

Kontermann, R. E., Münkel, S., Neumeyer, J., Müller, D., Branschädel, M., Scheurich, P., & Pfizenmaier, K. (2008). A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. Journal of Immunotherapy, 31(3), Article 3. https://doi.org/10.1097/CJI.0b013e31816a88f9

BECKER, E., FLORIN, L., PFIZENMAIER, K., & KAUFMANN, H. (2008). An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes. Journal of Biotechnology, 135(2), Article 2. https://doi.org/10.1016/j.jbiotec.2008.03.008

Müller, D., Trunk, G., Sichelstiel, A., Zettlitz, K. A., Quintanilla, M., & Kontermann, R. E. (2008). Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice. Journal of Immunological Methods, 339(1), Article 1. https://doi.org/10.1016/j.jim.2008.08.008

Johnson, T. S., Mahnke, K., Storn, V., Schönfeld, K., Ring, S., Nettelbeck, D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E., & Enk, A. H. (2008). Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable molecule. Clinical Cancer Research, 14(24), Article 24. https://doi.org/10.1158/1078-0432.CCR-08-1474

Chang, H. H., Wang, W., Bong, S. J., Wong, C., Hausser, A., Pfizenmaier, K., McKinsey, T. A., Olson, E. N., & Jin, Z. G. (2008). Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. Journal of Biological Chemistry, 283(21), Article 21. https://doi.org/10.1074/jbc.M800264200

Ellwanger, K., Pfizenmaier, K., Lutz, S., & Hausser, A. (2008). Expression patterns of protein kinase D 3 during mouse development. BMC Developmental Biology, 8, 47. https://doi.org/10.1186/1471-213X-8-47

Müller, N., Wyzgol, A., Münkel, S., Pfizenmaier, K., & Wajant, H. (2008). Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS Journal, 275(9), Article 9. https://doi.org/10.1111/j.1742-4658.2008.06382.x

Holeiter, G., Heering, J., Erlmann, P., Schmid, S., Jähne, R., & Olayioye, M. A. (2008). Deleted in liver cancer 1 controls cell migration through a dia1-dependent signaling pathway. Cancer Research, 68(21), Article 21. https://doi.org/10.1158/0008-5472.CAN-08-0984

Lasithiotakis, K. G., Sinnberg, T. W., Schittek, B., Flaherty, K. T., Kulms, D., Maczey, E., Garbe, C., & Meier, F. E. (2008). Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells. Journal of Investigative Dermatology, 128(8), Article 8. https://doi.org/10.1038/jid.2008.44

Singer-Krüger, B., Lasić, M., Bürger, A. M., Haußer, A., Pipkorn, R., & Wang, Y. (2008). Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO Journal, 27(10), Article 10. https://doi.org/10.1038/emboj.2008.75

Stork, R., Zettlitz, K. A., Müller, D., Rether, M., Hanisch, F. G., & Kontermann, R. E. (2008). N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies. Journal of Biological Chemistry, 283(12), Article 12. https://doi.org/10.1074/jbc.M709179200

Krippner-Heidenreich, A., Grunwald, I., Zimmermann, G., Kuhnle, M., Gerspach, J., Sterns, T., Shnyder, S. D., Gill, J. H., Mannel, D. N., Pfizenmaier, K., & Scheurich, P. (2008). Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity. The Journal of Immunology, 180(12), Article 12. https://doi.org/10.4049/jimmunol.180.12.8176

Müller, E., & Faude, A. (2008). Investigation of salt properties with electro-acoustic measurements and their effect on dynamic binding capacity in hydrophobic interaction chromatography. Journal of Chromatography A, 1177(2), Article 2. https://doi.org/10.1016/j.chroma.2007.11.008

Eißing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Steady state and (bi-) stability evaluation of simple protease signalling networks. Biosystems, 90(3), Article 3. https://doi.org/10.1016/j.biosystems.2007.01.003

Faude, A., Zacher, D., Müller, E., & Böttinger, H. (2007). Fast determination of conditions for maximum dynamic capacity in cation-exchange chromatography of human monoclonal antibodies. Journal of Chromatography A, 1161(1–2), Article 1–2. https://doi.org/10.1016/j.chroma.2007.03.114

Eissing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Response to bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophysical Journal, 92(9), Article 9. https://doi.org/10.1529/biophysj.106.100362

Berg, D., Lehne, M., Müller, N., Siegmund, D., Münkel, S., Sebald, W., Pfizenmaier, K., & Wajant, H. (2007). Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death and Differentiation, 14(12), Article 12. https://doi.org/10.1038/sj.cdd.4402213

Xu, X., Ha, C. H., Wong, C., Wang, W., Hausser, A., Pfizenmaier, K., Olson, E. N., McKinsey, T. A., & Jin, Z. G. (2007). Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(11), Article 11. https://doi.org/10.1161/ATVBAHA.107.151704

Müller, D., Karle, A., Meißburger, B., Höfig, I., Stork, R., & Kontermann, R. E. (2007). Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. Journal of Biological Chemistry, 282(17), Article 17. https://doi.org/10.1074/jbc.M700820200

Hesse, A., Kosmides, D., Kontermann, R. E., & Nettelbeck, D. M. (2007). Tropism Modification of Adenovirus Vectors by Peptide Ligand Insertion into Various Positions of the Adenovirus Serotype 41 Short-Fiber Knob Domain. Journal of Virology, 81(6), Article 6. https://doi.org/10.1128/JVI.02722-06

Fugmann, T., Hausser, A., Schöffler, P., Schmid, S., Pfizenmaier, K., & Olayioye, M. A. (2007). Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. Journal of Cell Biology, 178(1), Article 1. https://doi.org/10.1083/jcb.200612017

Baum, P., Müller, D., Rüger, R., & Kontermann, R. E. (2007). Single-chain Fv immunoliposomes for the targeting of fibroblast activation protein-expressing tumor stromal cells. Journal of Drug Targeting, 15(6), Article 6. https://doi.org/10.1080/10611860701453034

Meier, F., Busch, S., Lasithiotakis, K., Kulms, D., Garbe, C., Maczey, E., Herlyn, M., & Schittek, B. (2007). Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. British Journal of Dermatology, 156(6), Article 6. https://doi.org/10.1111/j.1365-2133.2007.07821.x

Witt, J., Husser, S., Kulms, D., Barisic, S., Sawodny, O., & Sauter, T. (2007). Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence. Proceedings of the SICE Annual Conference, 1353--1358. https://doi.org/10.1109/SICE.2007.4421193

Maier, D., Nagel, A. C., Gloc, H., Hausser, A., Kugler, S. J., Wech, I., & Preiss, A. (2007). Protein Kinase D regulates several aspects of development in Drosophila melanogaster. BMC Developmental Biology, 7, 74. https://doi.org/10.1186/1471-213X-7-74

Müller, D., & Kontermann, R. E. (2007). Recombinant bispecific antibodies for cellular cancer immunotherapy. Current opinion in molecular therapeutics, 9(4), Article 4. https://www.ncbi.nlm.nih.gov/pubmed/17694444

Eiseler, T., Schmid, M. A., Topbas, F., Pfizenmaier, K., & Hausser, A. (2007). PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Letters, 581(22), Article 22. https://doi.org/10.1016/j.febslet.2007.07.079

Stork, R., Müller, D., & Kontermann, R. E. (2007). A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Engineering, Design and Selection, 20(11), Article 11. https://doi.org/10.1093/protein/gzm061

Olayioye, M. A., Buchholz, M., Schmid, S., Schöffler, P., Hoffmann, P., & Pomorski, T. (2007). Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. Journal of Biological Chemistry, 282(31), Article 31. https://doi.org/10.1074/jbc.M701990200

Gerspach, J., Müller, D., Münkel, S., Selchow, O., Nemeth, J., Noack, M., Petrul, H., Menrad, A., Wajant, H., & Pfizenmaier, K. (2006). Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug. Cell Death and Differentiation, 13(2), Article 2. https://doi.org/10.1038/sj.cdd.4401735

Kontermann, R. E. (2006). Immunoliposomes for cancer therapy. Current opinion in molecular therapeutics, 8(1), Article 1. http://www.ncbi.nlm.nih.gov/pubmed/16506524

Rüger, R., Müller, D., Fahr, A., & Kontermann, R. E. (2006). In vitro characterization of binding and stability of single-chain Fv Ni-NTA-liposomes. Journal of Drug Targeting, 14(8), Article 8. https://doi.org/10.1080/10611860600864018

Beisner, J., Buck, M. B., Fritz, P., Dippon, J., Schwab, M., Brauch, H., Zugmaier, G., Pfizenmaier, K., & Knabbe, C. (2006). A Novel Functional Polymorphism in the Transforming Growth Factor-β2 Gene Promoter and Tumor Progression in Breast Cancer. Cancer Research, 66(15), Article 15. https://doi.org/10.1158/0008-5472.CAN-06-0634

Maier, D., Hausser, A., Nagel, A. C., Link, G., Kugler, S. J., Wech, I., Pfizenmaier, K., & Preiss, A. (2006). Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Gene Expression Patterns, 6(8), Article 8. https://doi.org/10.1016/j.modgep.2006.03.007

Strozyk, E., Pöppelmann, B., Schwarz, T., & Kulms, D. (2006). Differential effects of NF-κB on apoptosis induced by DNA-damaging agents: The type of DNA damage determines the final outcome. Oncogene, 25(47), Article 47. https://doi.org/10.1038/sj.onc.1209655

Gerspach, J., Németh, J., Münkel, S., Wajant, H., & Pfizenmaier, K. (2006). Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface. Cancer Immunology, Immunotherapy, 55(12), Article 12. https://doi.org/10.1007/s00262-006-0162-6

Hausser, A., Link, G., Hoene, M., Russo, C., Selchow, O., & Pfizenmaier, K. (2006). Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III β protects from dephosphorylation and stabilizes lipid kinase activity. Journal of Cell Science, 119(17), Article 17. https://doi.org/10.1242/jcs.03104

Watermann, I., Gerspach, J., Lehne, M., Seufert, J., Schneider, B., Pfizenmaier, K., & Wajant, H. (2006). Activation of CD95L fusion protein prodrugs by tumor-associated proteases. Cell Death And Differentiation, 14, 765--. http://dx.doi.org/10.1038/sj.cdd.4402051

Assohou-Luty, C., Gerspach, J., Siegmund, D., Müller, N., Huard, B., Tiegs, G., Pfizenmaier, K., & Wajant, H. (2006). A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95. Journal of Molecular Medicine, 84(9), Article 9. https://doi.org/10.1007/s00109-006-0073-1

Kulms, D., & Schwarz, T. (2006). NF-κB and Cytokines. Vitamins and Hormones, 74, 283--300. https://doi.org/10.1016/S0083-6729(06)74011-0