Publikationen

Nguyen, K. L., Bhatt, I. J., Gupta, S., Showkat, N., Swanson, K. A., Fischer, R., Kontermann, R. E., Pfizenmaier, K., Bracchi-Ricard, V., & Bethea, J. R. (2024). Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis. Brain Research Bulletin, 207, 110885. https://doi.org/10.1016/j.brainresbull.2024.110885

Klein, C., Brinkmann, U., Reichert, J. M., & Kontermann, R. E. (2024). The present and future of bispecific antibodies for cancer therapy. Nature Reviews Drug Discovery, 23, Article 4. https://doi.org/10.1038/s41573-024-00896-6

Köhler, A. R., Haußer, J., Harsch, A., Bernhardt, S., Häußermann, L., Brenner, L.-M., Lungu, C., Olayioye, M. A., Bashtrykov, P., & Jeltsch, A. (2024). Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells. Cell Reports Methods, 4, Article 4. https://doi.org/10.1016/j.crmeth.2024.100739

Frey, Y., Lungu, C., & Olayioye, M. A. (2024). Regulation and functions of the DLC family of RhoGAP proteins: Implications for development and cancer. Cellular Signalling, 125, 111505. https://doi.org/10.1016/j.cellsig.2024.111505

Schlett, K., Oueslati Morales, C. O., Bencsik, N., & Hausser, A. (2024). Getting smart – Deciphering the neuronal functions of protein kinase D. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1871, Article 7. https://doi.org/10.1016/j.bbamcr.2024.119812

Beigl, T. B., Paul, A., Fellmeth, T. P., Nguyen, D., Barber, L., Weller, S., Schäfer, B., Gillissen, B. F., Aulitzky, W. E., Kopp, H.-G., Rehm, M., Andrews, D. W., Pluhackova, K., & Essmann, F. (2024). BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains. EMBO Reports, 25, Article 9. https://doi.org/10.1038/s44319-024-00206-6

Entrop, K., Wieske, S., & Rehm, M. (2024). Why Bax detection in >1400 publications might be flawed. Cell Death & Disease, 15, Article 12. https://doi.org/10.1038/s41419-024-07273-6

Boccellato, C., & Rehm, M. (2024). TRAIL-induced apoptosis and proteasomal activity – Mechanisms, signalling and interplay. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 119688. https://doi.org/10.1016/j.bbamcr.2024.119688

Yang, H., Meyer, F., Huang, S., Yang, L., Lungu, C., Olayioye, M. A., Buehler, M. J., & Guo, M. (2024). Learning Collective Cell Migratory Dynamics from a Static Snapshot with Graph Neural Networks. PRX Life, 2, Article 4. https://doi.org/10.1103/PRXLife.2.043010

Frey, Y., Lungu, C., Meyer, F., Hauth, F., Hahn, D., Kersten, C., Heller, V., Franz-Wachtel, M., Macek, B., Barsukov, I., & Olayioye, M. A. (2024). Regulation of the DLC3 tumor suppressor by a novel phosphoswitch. iScience, 27, Article 7. https://doi.org/10.1016/j.isci.2024.110203

Brenner, L.-M., Meyer, F., Yang, H., Köhler, A. R., Bashtrykov, P., Guo, M., Jeltsch, A., Lungu, C., & Olayioye, M. A. (2024). Repeat DNA methylation is modulated by adherens junction signaling. Communications Biology, 7, Article 1. https://doi.org/10.1038/s42003-024-05990-4

Gali, A., Bijnsdorp, I. V., Piersma, S. R., Pham, T. V., Gutiérrez-Galindo, E., Kühnel, F., Tsolakos, N., Jimenez, C. R., Hausser, A., & Alexopoulos, L. G. (2024). Protein Kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines. iScience, 108958. https://doi.org/10.1016/j.isci.2024.108958

Liang, K. L., Roels, J., Lavaert, M., Putteman, T., Boehme, L., Tilleman, L., Velghe, I., Pegoretti, V., Van de Walle, I., Sontag, S., Vandewalle, J., Vandekerckhove, B., Leclercq, G., Van Vlierberghe, P., Libert, C., Van Nieuwerburgh, F., Fischer, R., Kontermann, R. E., Pfizenmaier, K., et al. (2023). Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nature Immunology. https://doi.org/10.1038/s41590-022-01417-6

Pegoretti, V., Bauer, J., Fischer, R., Paro, I., Douwenga, W., Kontermann, R. E., Pfizenmaier, K., Houben, E., Broux, B., Hellings, N., Baron, W., Laman, J. D., & Eisel, U. L. M. (2023). Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS. Journal of Neuroinflammation, 20, Article 1. https://doi.org/10.1186/s12974-023-02785-y

Fiedler, T., Fairless, R., Pichi, K., Fischer, R., Richter, F., Kontermann, R. E., Pfizenmaier, K., Diem, R., & Williams, S. K. (2023). Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis. Journal of Neuroinflammation, 20, Article 1. https://doi.org/10.1186/s12974-023-02784-z

Guttà, C., Morhard, C., & Rehm, M. (2023). Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer. PLOS Computational Biology, 19, Article 4. https://doi.org/10.1371/journal.pcbi.1011035

S, S., F, E., AF, G., H, H., J, S., A, H., L, S., G, O., & C, K. (2023). Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in Oncology. https://doi.org/10.3389/fonc.2023.1190988

Steinlein, S., Essmann, F., Ghilardi, A. F., Horn, H., Schüler, J., Hausser, A., Sun, L., Ott, G., & Kalla, C. (2023). Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in Oncology, 13, 1190988. https://doi.org/10.3389/fonc.2023.1190988

Lungu, C., Meyer, F., Hörning, M., Steudle, J., Braun, A., Noll, B., Benz, D., Fränkle, F., Schmid, S., Eisler, S. A., Olayioye, M. A., & Monilola Olayioye, C. A. (2023). Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport. Traffic. https://doi.org/10.1111/TRA.12880

Gutiérrez-Galindo, E., Yilmaz, Z. H., & Hausser, A. (2023). Membrane trafficking in breast cancer progression: protein kinase D comes into play. Frontiers in Cell and Developmental Biology, 11, 1173387. https://doi.org/10.3389/fcell.2023.1173387

Ortí-Casañ, N., Boerema, A. S., Köpke, K., Ebskamp, A., Keijser, J., Zhang, Y., Chen, T., Dolga, A. M., Broersen, K., Fischer, R., Pfizenmaier, K., Kontermann, R. E., & Eisel, U. L. M. (2023). The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration. Scientific Reports, 13, Article 1. https://doi.org/10.1038/s41598-023-36846-2

Kühl, L., Schäfer, A. K., Kraft, S., Aschmoneit, N., Kontermann, R. E., & Seifert, O. (2023). eIg-based bispecific T-cell engagers targeting EGFR: Format matters. mAbs, 15, Article 1. https://doi.org/10.1080/19420862.2023.2183540

Fullstone, G. (2023). Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs. In Methods in Molecular Biology (pp. 191–212). Springer US. https://doi.org/10.1007/978-1-0716-3008-2_9

Abassi, L., Bertoglio, F., Mačak Šafranko, Ž., Schirrmann, T., Greweling-Pils, M., Seifert, O., Khan, F., Katzmarzyk, M., Jacobsen, H., Gödecke, N., Heine, P. A., Frenzel, A., Nowack, H., Dübel, S., Kurolt, I.-C., Kontermann, R. E., Markotić, A., Schubert, M., Hust, M., & Čičin-Šain, L. (2023). Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns. Viruses, 15, Article 11. https://doi.org/10.3390/v15112153

N, B., CO, O. M., A, H., & K, S. (2023). Endocytosis of AMPA receptors: Role in neurological conditions. Progress in Molecular Biology and Translational Science. https://doi.org/10.1016/bs.pmbts.2022.09.007

A, I., D, N.-H., A, H., & K, S. (2023). Dendritic effects of genetically encoded actin-labeling probes in cultured hippocampal neurons. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e22-08-0331

Müller, D. (2023). Targeting Co-Stimulatory Receptors of the TNF Superfamily for Cancer Immunotherapy. BioDrugs, 37, Article 1. https://doi.org/10.1007/s40259-022-00573-3

E, G.-G., ZH, Y., & A, H. (2023). Membrane trafficking in breast cancer progression: protein kinase D comes into play. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2023.1173387

R, R., K, H., G, L., SA, E., T, H., MAH, P., JE, B., A, H., & TA, L. (2023). PKD autoinhibition in <i>trans</i> regulates activation loop autophosphorylation in <i>cis</i>. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2212909120

Reinhardt, R., Hirzel, K., Link, G., Eisler, S. A., Hägele, T., Parson, M. A. H., Burke, J. E., Hausser, A., & Leonard, T. A. (2023). PKD autoinhibition in trans regulates activation loop autophosphorylation in cis. Proceedings of the National Academy of Sciences, 120, Article 7. https://doi.org/10.1073/pnas.2212909120

Ignácz, A., Nagy-Herczeg, D., Hausser, A., & Schlett, K. (2023). Dendritic effects of genetically encoded actin labelling probes in cultured hippocampal neurons. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e22-08-0331

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J., et al. (2023). Apoptotic cell death in disease---Current understanding of the NCCD 2023. Cell Death & Differentiation, 30, Article 5. https://doi.org/10.1038/s41418-023-01153-w

Katiyar, P., Schwenck, J., Frauenfeld, L., Divine, M. R., Agrawal, V., Kohlhofer, U., Gatidis, S., Kontermann, R., Königsrainer, A., Quintanilla-Martinez, L., la Fougère, C., Schölkopf, B., Pichler, B. J., & Disselhorst, J. A. (2023). Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data. Nature Biomedical Engineering, 10. https://doi.org/10.1038/s41551-023-01047-9

Müller, D. (2022). Optimized CD19/CD22/CD3 antibody. Blood, 140, Article 16. https://doi.org/10.1182/blood.2022018081

Aschmoneit, N., Kocher, K., Siegemund, M., Lutz, M. S., Kühl, L., Seifert, O., & Kontermann, R. E. (2022). Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc). Oncoimmunology, 11, Article 1. https://doi.org/10.1080/2162402X.2022.2028961

Rau, A., Janssen, N., Kühl, L., Sell, T., Kalmykova, S., Mürdter, T. E., Dahlke, M.-H., Sers, C., Morkel, M., Schwab, M., Kontermann, R. E., & Olayioye, M. A. (2022). Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancerTriple HER blockade in CRC. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-21-0818

Del Mistro, G., Riemann, S., Schindler, S., Beissert, S., Kontermann, R. E., Ginolhac, A., Halder, R., Presta, L., Sinkkonen, L., Sauter, T., & Kulms, D. (2022). Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma. Cell Death & Disease, 13, Article 1. https://doi.org/10.1038/s41419-022-04502-8

Dilchert, J., Hofmann, M., Unverdorben, F., Kontermann, R., & Bunk, S. (2022). Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules. Antibodies, 11, Article 2. https://doi.org/10.3390/antib11020034

Guttà, C., Morhard, C., & Rehm, M. (2022, October). T-GAN-D: a GAN-based classifier for breast cancer prognostication [Zenodo]. https://doi.org/10.5281/zenodo.7151831

Hagenlocher, C., Siebert, R., Taschke, B., Wieske, S., Hausser, A., & Rehm, M. (2022). ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery, 8, Article 1. https://doi.org/10.1038/s41420-022-00830-y

Bencsik, N., Oueslati Morales, C. O., Hausser, A., & Schlett, K. (2022). Endocytosis of AMPA receptors: Role in neurological conditions. Academic Press. https://doi.org/10.1016/bs.pmbts.2022.09.007

Mora-Molina, R., Stöhr, D., Rehm, M., & López-Rivas, A. (2022). cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. Cell Death & Disease, 13, Article 2. https://doi.org/10.1038/s41419-022-04574-6

Guttà, C., Morhard, C., & Rehm, M. (2022). Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer. In medRxiv. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/2022.10.07.22280776

Frey, Y., Franz-Wachtel, M., Macek, B., & Olayioye, M. A. (2022). Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Scientific Reports 2022 12:1, 12, Article 1. https://doi.org/10.1038/s41598-022-08844-3

Kühl, L., Aschmoneit, N., Kontermann, R. E., & Seifert, O. (2022). The eIg technology to generate Ig-like bispecific antibodies. mAbs, 14, Article 1. https://doi.org/10.1080/19420862.2022.2063043

Boccellato, C., & Rehm, M. (2022). Glioblastoma, from disease understanding towards optimal cell-based in vitro models. Cellular Oncology. https://doi.org/10.1007/s13402-022-00684-7

Seifert, O., & Kontermann, R. E. (2022). GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments. Molecules (Basel, Switzerland), 27, Article 10. https://doi.org/10.3390/molecules27103272

Ludwig-Słomczyńska, A. H., & Rehm, M. (2022). Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases. Obesity. https://doi.org/10.1002/OBY.23424

C, H., R, S., B, T., S, W., A, H., & M, R. (2022). ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery. https://doi.org/10.1038/s41420-022-00830-y

Vera, J., Lai, X., Baur, A., Erdmann, M., Gupta, S., Guttà, C., Heinzerling, L., Heppt, M. V., Kazmierczak, P. M., Kunz, M., Lischer, C., Pützer, B. M., Rehm, M., Ostalecki, C., Retzlaff, J., Witt, S., Wolkenhauer, O., & Berking, C. (2022). Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence. Briefings in Bioinformatics. https://doi.org/10.1093/BIB/BBAC433

Richter, F., Williams, S. K., John, K., Huber, C., Vaslin, C., Zanker, H., Fairless, R., Pichi, K., Marhenke, S., Vogel, A., Dhaen, M.-A., Herrmann, S., Herrmann, A., Pfizenmaier, K., Bantel, H., Diem, R., Kontermann, R. E., & Fischer, R. (2021). The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705485

Juric, V., Düssmann, H., Lamfers, M. L. M., Prehn, J. H. M., Rehm, M., & Murphy, B. M. (2021). Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells 2021, Vol. 10, Page 1182, 10, Article 5. https://doi.org/10.3390/cells10051182

Lindner, A. U., Salvucci, M., McDonough, E., Cho, S., Stachtea, X., O’Connell, E. P., Corwin, A. D., Santamaria-Pang, A., Carberry, S., Fichtner, M., Van Schaeybroeck, S., Laurent-Puig, P., Burke, J. P., McNamara, D. A., Lawler, M., Sood, A., Graf, J. F., Rehm, M., Dunne, P. D., et al. (2021). An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell Death & Differentiation. https://doi.org/10.1038/s41418-021-00895-9

Aschmoneit, N., Steinlein, S., Kühl, L., Seifert, O., & Kontermann, R. E. (2021). A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells. Scientific Reports, 11, Article 1. https://doi.org/10.1038/S41598-021-93351-0

Massafra, V., Tundo, S., Dietzig, A., Ducret, A., Jost, C., Klein, C., Kontermann, R. E., Knoetgen, H., Steegmaier, M., Romagnani, A., & Nagel, Y. A. (2021). Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000252

Hellwig, C. T., Delgado, M. E., Skoko, J., Dyck, L., Hanna, C., Wentges, A., Langlais, C., Hagenlocher, C., Mack, A., Dinsdale, D., Cain, K., MacFarlane, M., & Rehm, M. (2021). Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death & Differentiation 2021, 1–9. https://doi.org/10.1038/s41418-021-00843-7

Boccellato, C., Kolbe, E., Peters, N., Juric, V., Fullstone, G., Verreault, M., Idbaih, A., Lamfers, M. L. M., Murphy, B. M., & Rehm, M. (2021). Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell Death & Disease, 12, Article 7. https://doi.org/10.1038/s41419-021-03927-x

Ehlers, W., Morrison (Rehm), M., Schröder, P., Stöhr, D., & Wagner, A. (2021). Multiphasic modelling and computation of metastatic lung-cancer cell proliferation and atrophy in brain tissue based on experimental data. Biomechanics and Modeling in Mechanobiology. https://doi.org/10.1007/s10237-021-01535-4

Aschmoneit, N., Kühl, L., Seifert, O., & Kontermann, R. E. (2021). Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release. Journal for Immunotherapy of Cancer, 9, Article 11. https://doi.org/10.1136/jitc-2021-003616

Pollak, N., Lindner, A., Imig, D., Kuritz, K., Fritze, J. S., Decker, L., Heinrich, I., Stadager, J., Eisler, S., Stöhr, D., Allgöwer, F., Scheurich, P., & Rehm, M. (2021). Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis. Journal of Cell Science, jcs. https://doi.org/10.1242/jcs.258966

Bethea, J. R., & Fischer, R. (2021). Role of peripheral immune cells for development and recovery of chronic pain. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.641588

Brinkmann, U., & Kontermann, R. E. (2021). Bispecific antibodies. Science, 372, Article 6545. https://doi.org/10.1126/science.abg1209

Oueslati Morales, C. O., Ignácz, A., Bencsik, N., Sziber, Z., Rátkai, A. E., Lieb, W. S., Eisler, S. A., Szűcs, A., Schlett, K., & Hausser, A. (2021). Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic, n/a, Article n/a. https://doi.org/10.1111/tra.12819

CO, O. M., A, I., N, B., Z, S., AE, R., WS, L., SA, E., A, S., K, S., & A, H. (2021). Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic (Copenhagen, Denmark). https://doi.org/10.1111/tra.12819

Siegemund, M., Oak, P., Hansbauer, E.-M., Allersdorfer, A., Utschick, K., Winter, A., Grasmüller, C., Galler, G., Mayer, J.-P., Weiche, B., Prassler, J., Kontermann, R. E., & Rothe, C. (2021). Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Frontiers in Pharmacology, 12, 759337. https://doi.org/10.3389/fphar.2021.759337

Juric, V., Hudson, L., Fay, J., Richards, C. E., Jahns, H., Verreault, M., Bielle, F., Idbaih, A., Lamfers, M. L. M., Hopkins, A. M., Rehm, M., & Murphy, B. M. (2021). Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Cell Death & Disease 2021 12:8, 12, Article 8. https://doi.org/10.1038/s41419-021-04050-7

McCann, C., Matveeva, A., McAllister, K., Sessler, T., Fichtner, M., Carberry, S., Rehm, M., Prehn, J. H. M., & Longley, D. B. (2021). Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. The FEBS Journal, febs. https://doi.org/10.1111/febs.15801

Papazian, I., Tsoukala, E., Boutou, A., Karamita, M., Kambas, K., Iliopoulou, L., Fischer, R., Kontermann, R. E., Denis, M. C., Kollias, G., Lassmann, H., & Probert, L. (2021). Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. Journal of Neuroinflammation, 18, Article 1. https://doi.org/10.1186/s12974-021-02200-4

Rau, A., Kocher, K., Rommel, M., Kühl, L., Albrecht, M., Gotthard, H., Aschmoneit, N., Noll, B., Olayioye, M. A., Kontermann, R. E., & Seifert, O. (2021). A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3. mAbs, 13, Article 1. https://doi.org/10.1080/19420862.2021.1902034

Kontermann, R. E., Ungerechts, G., & Nettelbeck, D. M. (2021). Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics. mAbs, 13, Article 1. https://doi.org/10.1080/19420862.2021.1982447

Krishna Moorthy, N., Seifert, O., Eisler, S., Weirich, S., Kontermann, R. E., Rehm, M., & Fullstone, G. (2021). Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma. Molecules 2021, Vol. 26, Page 7582, 26, Article 24. https://doi.org/10.3390/MOLECULES26247582

Zhang, S., Liu, H., Yin, M., Pei, X., Hausser, A., Ishikawa, E., Yamasaki, S., & Jin, Z. G. (2020). Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice. Hepatology, hep. https://doi.org/10.1002/hep.31176

Stöhr, D., Jeltsch, A., & Rehm, M. (2020). TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response. Int Rev Cell Mol Biol, 351, 57–99. https://doi.org/10.1016/bs.ircmb.2020.02.002

Fullstone, G., Bauer, T. L., Guttà, C., Salvucci, M., Prehn, J. H. M., & Rehm, M. (2020). The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell Death & Differentiation. https://doi.org/10.1038/s41418-020-0545-9

Imig, D., Pollak, N., Allgöwer, F., & Rehm, M. (2020). Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis. PLOS Computational Biology, 16, Article 6. https://doi.org/10.1371/journal.pcbi.1007812

Wandrer, F., Liebig, S., Marhenke, S., Vogel, A., John, K., Manns, M. P., Teufel, A., Itzel, T., Longerich, T., Maier, O., Fischer, R., Kontermann, R. E., Pfizenmaier, K., Schulze-Osthoff, K., & Bantel, H. (2020). TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice. Cell Death Dis, 11, Article 3. https://doi.org/10.1038/s41419-020-2411-6

Tansi, F. L., Rüger, R., Kollmeier, A. M., Rabenhold, M., Steiniger, F., Kontermann, R. E., Teichgräber, U. K., Fahr, A., & Hilger, I. (2020). Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes. Pharmaceutics, 12, Article 4. https://doi.org/10.3390/pharmaceutics12040370

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Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes. Antibodies, 1, Article 3. https://doi.org/10.3390/antib1020199

Eisler, S. A., Fuchs, Y. F., Pfizenmaier, K., & Hausser, A. (2012). G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-network. Biotechnology Journal, 7, Article 1. https://doi.org/10.1002/biot.201100273

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Siegemund, M., Pollak, N., Seifert, O., Wahl, K., Hanak, K., Vogel, A., Nussler, A. K., Göttsch, D., Münkel, S., Bantel, H., Kontermann, R. E., & Pfizenmaier, K. (2012). Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. Cell Death and Disease, 3, Article 4. https://doi.org/10.1038/cddis.2012.29

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Hornig, N., Kermer, V., Frey, K., Diebolder, P., Kontermann, R. E., & Müller, D. (2012). Combination of a bispecific antibody and costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy. Journal of Immunotherapy, 35, Article 5. https://doi.org/10.1097/CJI.0b013e3182594387

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Gehrmann, M., Doß, B. T., Wagner, M., Zettlitz, K. A., Kontermann, R. E., Foulds, G., Pockley, A. G., & Multhoff, G. (2011). A novel expression and purification system for the production of enzymatic and biologically active human granzyme B. Journal of Immunological Methods, 371, Article 1–2. https://doi.org/10.1016/j.jim.2011.06.007

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Baum, P., Fundel-Clemens, K., Kreuz, S., Kontermann, R. E., Weith, A., Mennerich, D., & Rippmann, J. F. (2010). Off-target analysis of control siRNA molecules reveals important differences in the cytokine profile and inflammation response of human fibroblasts. Oligonucleotides, 20, Article 1. https://doi.org/10.1089/oli.2009.0213

Rothdiener, M., Müller, D., Castro, P. G., Scholz, A., Schwemmlein, M., Fey, G., Heidenreich, O., & Kontermann, R. E. (2010). Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems. Journal of Controlled Release, 144, Article 2. https://doi.org/10.1016/j.jconrel.2010.02.020

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Boschert, V., Krippner-Heidenreich, A., Branschädel, M., Tepperink, J., Aird, A., & Scheurich, P. (2010). Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. Cellular Signalling, 22, Article 7. https://doi.org/10.1016/j.cellsig.2010.02.011

S, B., K, E., C, B.-G., M, S., A, H., I, S., & S, B.-H. (2010). SLy2 targets the nuclear SAP30/HDAC1 complex. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/j.biocel.2010.05.004

Hopp, J., Hornig, N., Zettlitz, K. A., Schwarz, A., Fuß, N., Müller, D., & Kontermann, R. E. (2010). The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Engineering, Design and Selection, 23, Article 11. https://doi.org/10.1093/protein/gzq058

Brandt, S., Ellwanger, K., Beuter-Gunia, C., Schuster, M., Hausser, A., Schmitz, I., & Beer-Hammer, S. (2010). SLy2 targets the nuclear SAP30/HDAC1 complex. International Journal of Biochemistry and Cell Biology, 42, Article 9. https://doi.org/10.1016/j.biocel.2010.05.004

Schneider, B., Münkel, S., Krippner-Heidenreich, A., Grunwald, I., Wels, W. S., Wajant, H., Pfizenmaier, K., & Gerspach, J. (2010). Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins. Cell Death and Disease, 1, Article 8. https://doi.org/10.1038/cddis.2010.45

Branschädel, M., Aird, A., Zappe, A., Tietz, C., Krippner-Heidenreich, A., & Scheurich, P. (2010). Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness. Cellular Signalling, 22, Article 3. https://doi.org/10.1016/j.cellsig.2009.10.011

Gerken, M., Krippner-Heidenreich, A., Steinert, S., Willi, S., Neugart, F., Zappe, A., Wrachtrup, J., Tietz, C., & Scheurich, P. (2010). Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors. Biochimica et Biophysica Acta - Biomembranes, 1798, Article 6. https://doi.org/10.1016/j.bbamem.2010.02.021

Anliker, B., Abel, T., Kneissl, S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C., Münch, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Müller, U. C., Hohenadl, C., Monyer, H., Cichutek, K., & Buchholz, C. J. (2010). Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nature Methods, 7, 929––. http://dx.doi.org/10.1038/nmeth.1514

T, E., A, H., L, D. K., J, V. L., & K, P. (2010). Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. The Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109.093880

Ranzinger, J., Krippner-Heidenreich, A., Haraszti, T., Bock, E., Tepperink, J., Spatz, J. P., & Scheurich, P. (2009). Nanoscale arrangement of apoptotic ligands reveals a demand for a minimal lateral distance for efficient death receptor activation. Nano Letters, 9, Article 12. https://doi.org/10.1021/nl902429b

Gerspach, J., Pfizenmaier, K., & Wajant, H. (2009). Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. BioFactors, 35, Article 4. https://doi.org/10.1002/biof.50

Gerspach, J., Wajant, H., & Pfizenmaier, K. (2009). Death ligands designed to kill: Development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands. Results and Problems in Cell Differentiation, 49, 241–273. https://doi.org/10.1007/400_2008_22

Kontermann, R. E., Scheurich, P., & Pfizenmaier, K. (2009). Antagonists of TNF action: clinical experience and new developments. Expert Opinion on Drug Discovery, 4, Article 3. https://doi.org/10.1517/17460440902785167

Breindl, C., Waldherr, S., Hausser, A., & Allgöwer, F. (2009). MODELING COFILIN MEDIATED REGULATION OF CELL MIGRATION AS A BIOCHEMICAL TWO-INPUT SWITCH. Proc.Of the 3rd Foundations of Systems Biology in Engineering (FOSBE), 60–63. https://lirias.kuleuven.be/bitstream/123456789/568203/1/BreindlWal2009.pdf

Czöndör, K., Ellwanger, K., Fuchs, Y. F., Lutz, S., Gulyás, M., Mansuy, I. M., Hausser, A., Pfizenmaier, K., & Schlett, K. (2009). Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Molecular Biology of the Cell, 20, Article 7. https://doi.org/10.1091/mbc.E08-09-0957

Ahmadvand, D., Rasaee, M. J., Rahbarizadeh, F., Kontermann, R. E., & Sheikholislami, F. (2009). Cell selection and characterization of a novel human endothelial cell specific nanobody. Molecular Immunology, 46, Article 8–9. https://doi.org/10.1016/j.molimm.2009.01.021

Kontermann, R. E. (2009). Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs, 23, Article 2. https://doi.org/10.2165/00063030-200923020-00003

Cowell, C. F., Doppler, H., Yan, I. K., Hausser, A., Umezawa, Y., & Storz, P. (2009). Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling. Journal of Cell Science, 122, Article 7. https://doi.org/10.1242/jcs.041061

Stork, R., Campigna, E., Robert, B., Müller, D., & Kontermann, R. E. (2009). Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. Journal of Biological Chemistry, 284, Article 38. https://doi.org/10.1074/jbc.M109.027078

Messerschmidt, S. K. E., Musyanovych, A., Altvater, M., Scheurich, P., Pfizenmaier, K., Landfester, K., & Kontermann, R. E. (2009). Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells. Journal of Controlled Release, 137, Article 1. https://doi.org/10.1016/j.jconrel.2009.03.010

Heering, J., Erlmann, P., & Olayioye, M. A. (2009). Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. Experimental Cell Research, 315, Article 15. https://doi.org/10.1016/j.yexcr.2009.05.022

RP, S., J, R., A, T., P, E., G, H., R, J., S, S., A, H., & MA, O. (2009). DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. Journal of Cell Science. https://doi.org/10.1242/jcs.036251

Thayaparasingham, B., Kunz, A., & Kulms, D. (2009). Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP. Oncogene, 28, Article 3. https://doi.org/10.1038/onc.2008.397

Sinnberg, T., Lasithiotakis, K., Niessner, H., Schittek, B., Flaherty, K. T., Kulms, D., Maczey, E., Campos, M., Gogel, J., Garbe, C., & Meier, F. (2009). Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide. Journal of Investigative Dermatology, 129, Article 6. https://doi.org/10.1038/jid.2008.379

Fuchs, Y. F., Eisler, S. A., Link, G., Schlicker, O., Bunt, G., Pfizenmaier, K., & Hausser, A. (2009). A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal. Traffic, 10, Article 7. https://doi.org/10.1111/j.1600-0854.2009.00918.x

Scholz, R.-P., Regner, J., Theil, A., Erlmann, P., Holeiter, G., Jähne, R., Schmid, S., Hausser, A., & Olayioye, M. a. (2009). DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. Journal of Cell Science, 122, Article Pt 1. https://doi.org/10.1242/jcs.036251

P, P., J, H., G, L., K, P., MA, O., & A, H. (2009). Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-0718

Wyzgol, A., Muller, N., Fick, A., Munkel, S., Grigoleit, G. U., Pfizenmaier, K., & Wajant, H. (2009). Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand. The Journal of Immunology, 183, Article 3. https://doi.org/10.4049/jimmunol.0802597

Witt, J., Barisic, S., Schumann, E., Allgöwer, F., Sawodny, O., Sauter, T., & Kulms, D. (2009). Mechanism of PP2A-mediated IKKβ dephosphorylation: A systems biological approach. BMC Systems Biology, 3, 71. https://doi.org/10.1186/1752-0509-3-71

L, F., A, P., E, B., A, H., MA, O., & H, K. (2009). Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. Journal of Biotechnology. https://doi.org/10.1016/j.jbiotec.2009.02.014

Schlatter, R., Schmich, K., Vizcarra, I. A., Scheurich, P., Sauter, T., Borner, C., Ederer, M., Merfort, I., & Sawodny, O. (2009). ON/OFF and beyond - A Boolean model of apoptosis. PLoS Computational Biology, 5, Article 12. https://doi.org/10.1371/journal.pcbi.1000595

Beuttler, J., Rothdiener, M., Müller, D., Frejd, F. Y., & Kontermann, R. E. (2009). Targeting of Epidermal Growth Factor Receptor (EGFR)-Expressing Tumor Cells with Sterically Stabilized Affibody Liposomes (SAL). Bioconjugate Chemistry, 20, Article 6. https://doi.org/10.1021/bc900061v

Florin, L., Pegel, A., Becker, E., Hausser, A., Olayioye, M. A., & Kaufmann, H. (2009). Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. Journal of Biotechnology, 141, Article 1–2. https://doi.org/10.1016/j.jbiotec.2009.02.014

Wicovsky, A., Henkler, F., Salzmann, S., Scheurich, P., Kneitz, C., & Wajant, H. (2009). Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene, 28, Article 15. https://doi.org/10.1038/onc.2009.29

YF, F., SA, E., G, L., O, S., G, B., K, P., & A, H. (2009). A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal. Traffic (Copenhagen, Denmark). https://doi.org/10.1111/j.1600-0854.2009.00918.x

Erlmann, P., Schmid, S., Horenkamp, F. A., Geyer, M., Pomorski, T. G., & Olayioye, M. A. (2009). DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain. Molecular Biology of the Cell, 20, Article 20. https://doi.org/10.1091/mbc.E09-03-0247

Peterburs, P., Heering, J., Link, G., Pfizenmaier, K., Olayioye, M. A., & Hausser, A. (2009). Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Research, 69, Article 14. https://doi.org/10.1158/0008-5472.CAN-09-0718

K, C., K, E., YF, F., S, L., M, G., IM, M., A, H., K, P., & K, S. (2009). Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e08-09-0957

C, K., A, R., G, B., K, H., A, H., R, D., & M, S. (2009). Proteinase-activated receptors 1 and 2 activate protein kinase D1 in human melanoma cells. Cell Communication and Signaling : CCS. https://doi.org/10.1186/1478-811x-7-s1-a99

CF, C., H, D., IK, Y., A, H., Y, U., & P, S. (2009). Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. Journal of Cell Science. https://doi.org/10.1242/jcs.041061

Müller, D., Frey, K., & Kontermann, R. E. (2008). A novel antibody-4-1BBL fusion protein for targeted costimulation in cancer immunotherapy. Journal of Immunotherapy, 31, Article 8. https://doi.org/10.1097/CJI.0b013e31818353e9

Kontermann, R. E., Münkel, S., Neumeyer, J., Müller, D., Branschädel, M., Scheurich, P., & Pfizenmaier, K. (2008). A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. Journal of Immunotherapy, 31, Article 3. https://doi.org/10.1097/CJI.0b013e31816a88f9

BECKER, E., FLORIN, L., PFIZENMAIER, K., & KAUFMANN, H. (2008). An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes. Journal of Biotechnology, 135, Article 2. https://doi.org/10.1016/j.jbiotec.2008.03.008

Messerschmidt, S. K. E., Kolbe, A., Müller, D., Knoll, M., Pleiss, J., & Kontermann, R. E. (2008). Novel single-chain Fv′ formats for the generation of immunoliposomes by site-directed coupling. Bioconjugate Chemistry, 19, Article 1. https://doi.org/10.1021/bc700349k

Barisic, S., Strozyk, E., Peters, N., Walczak, H., & Kulms, D. (2008). Identification of PP2A as a crucial regulator of the NF-$\kappa$B feedback loop: Its inhibition by UVB turns NF-κB into a pro-apoptotic factor. Cell Death and Differentiation, 15, Article 11. https://doi.org/10.1038/cdd.2008.98

Müller, D., Trunk, G., Sichelstiel, A., Zettlitz, K. A., Quintanilla, M., & Kontermann, R. E. (2008). Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice. Journal of Immunological Methods, 339, Article 1. https://doi.org/10.1016/j.jim.2008.08.008

Johnson, T. S., Mahnke, K., Storn, V., Schönfeld, K., Ring, S., Nettelbeck, D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E., & Enk, A. H. (2008). Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable molecule. Clinical Cancer Research, 14, Article 24. https://doi.org/10.1158/1078-0432.CCR-08-1474

Chang, H. H., Wang, W., Bong, S. J., Wong, C., Hausser, A., Pfizenmaier, K., McKinsey, T. A., Olson, E. N., & Jin, Z. G. (2008). Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. Journal of Biological Chemistry, 283, Article 21. https://doi.org/10.1074/jbc.M800264200

Ellwanger, K., Pfizenmaier, K., Lutz, S., & Hausser, A. (2008). Expression patterns of protein kinase D 3 during mouse development. BMC Developmental Biology, 8, 47. https://doi.org/10.1186/1471-213X-8-47

Müller, N., Wyzgol, A., Münkel, S., Pfizenmaier, K., & Wajant, H. (2008). Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS Journal, 275, Article 9. https://doi.org/10.1111/j.1742-4658.2008.06382.x

Holeiter, G., Heering, J., Erlmann, P., Schmid, S., Jähne, R., & Olayioye, M. A. (2008). Deleted in liver cancer 1 controls cell migration through a dia1-dependent signaling pathway. Cancer Research, 68, Article 21. https://doi.org/10.1158/0008-5472.CAN-08-0984

Lasithiotakis, K. G., Sinnberg, T. W., Schittek, B., Flaherty, K. T., Kulms, D., Maczey, E., Garbe, C., & Meier, F. E. (2008). Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells. Journal of Investigative Dermatology, 128, Article 8. https://doi.org/10.1038/jid.2008.44

Singer-Krüger, B., Lasić, M., Bürger, A. M., Haußer, A., Pipkorn, R., & Wang, Y. (2008). Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO Journal, 27, Article 10. https://doi.org/10.1038/emboj.2008.75

Stork, R., Zettlitz, K. A., Müller, D., Rether, M., Hanisch, F. G., & Kontermann, R. E. (2008). N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies. Journal of Biological Chemistry, 283, Article 12. https://doi.org/10.1074/jbc.M709179200

CH, H., W, W., BS, J., C, W., A, H., K, P., TA, M., EN, O., & ZG, J. (2008). Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. The Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m800264200

K, E., K, P., S, L., & A, H. (2008). Expression patterns of protein kinase D 3 during mouse development. BMC Developmental Biology. https://doi.org/10.1186/1471-213x-8-47

Müller, E., & Faude, A. (2008). Investigation of salt properties with electro-acoustic measurements and their effect on dynamic binding capacity in hydrophobic interaction chromatography. Journal of Chromatography A, 1177, Article 2. https://doi.org/10.1016/j.chroma.2007.11.008

Krippner-Heidenreich, A., Grunwald, I., Zimmermann, G., Kuhnle, M., Gerspach, J., Sterns, T., Shnyder, S. D., Gill, J. H., Mannel, D. N., Pfizenmaier, K., & Scheurich, P. (2008). Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity. The Journal of Immunology, 180, Article 12. https://doi.org/10.4049/jimmunol.180.12.8176

B, S.-K., M, L., AM, B., A, H., R, P., & Y, W. (2008). Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. The EMBO Journal. https://doi.org/10.1038/emboj.2008.75

Faude, A., Zacher, D., Müller, E., & Böttinger, H. (2007). Fast determination of conditions for maximum dynamic capacity in cation-exchange chromatography of human monoclonal antibodies. Journal of Chromatography A, 1161, Article 1–2. https://doi.org/10.1016/j.chroma.2007.03.114

Eissing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Response to bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophysical Journal, 92, Article 9. https://doi.org/10.1529/biophysj.106.100362

Berg, D., Lehne, M., Müller, N., Siegmund, D., Münkel, S., Sebald, W., Pfizenmaier, K., & Wajant, H. (2007). Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death and Differentiation, 14, Article 12. https://doi.org/10.1038/sj.cdd.4402213

Xu, X., Ha, C. H., Wong, C., Wang, W., Hausser, A., Pfizenmaier, K., Olson, E. N., McKinsey, T. A., & Jin, Z. G. (2007). Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, Article 11. https://doi.org/10.1161/ATVBAHA.107.151704

Eißing, T., Waldherr, S., Allgöwer, F., Scheurich, P., & Bullinger, E. (2007). Steady state and (bi-) stability evaluation of simple protease signalling networks. Biosystems, 90, Article 3. https://doi.org/10.1016/j.biosystems.2007.01.003

Müller, D., Karle, A., Meißburger, B., Höfig, I., Stork, R., & Kontermann, R. E. (2007). Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. Journal of Biological Chemistry, 282, Article 17. https://doi.org/10.1074/jbc.M700820200

X, X., CH, H., C, W., W, W., A, H., K, P., EN, O., TA, M., & ZG, J. (2007). Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.107.151704

T, E., MA, S., F, T., K, P., & A, H. (2007). PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Letters. https://doi.org/10.1016/j.febslet.2007.07.079

Baum, P., Müller, D., Rüger, R., & Kontermann, R. E. (2007). Single-chain Fv immunoliposomes for the targeting of fibroblast activation protein-expressing tumor stromal cells. Journal of Drug Targeting, 15, Article 6. https://doi.org/10.1080/10611860701453034

Hesse, A., Kosmides, D., Kontermann, R. E., & Nettelbeck, D. M. (2007). Tropism Modification of Adenovirus Vectors by Peptide Ligand Insertion into Various Positions of the Adenovirus Serotype 41 Short-Fiber Knob Domain. Journal of Virology, 81, Article 6. https://doi.org/10.1128/JVI.02722-06

Fugmann, T., Hausser, A., Schöffler, P., Schmid, S., Pfizenmaier, K., & Olayioye, M. A. (2007). Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. Journal of Cell Biology, 178, Article 1. https://doi.org/10.1083/jcb.200612017

Meier, F., Busch, S., Lasithiotakis, K., Kulms, D., Garbe, C., Maczey, E., Herlyn, M., & Schittek, B. (2007). Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. British Journal of Dermatology, 156, Article 6. https://doi.org/10.1111/j.1365-2133.2007.07821.x

Witt, J., Husser, S., Kulms, D., Barisic, S., Sawodny, O., & Sauter, T. (2007). Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence. Proceedings of the SICE Annual Conference, 1353–1358. https://doi.org/10.1109/SICE.2007.4421193

Maier, D., Nagel, A. C., Gloc, H., Hausser, A., Kugler, S. J., Wech, I., & Preiss, A. (2007). Protein Kinase D regulates several aspects of development in Drosophila melanogaster. BMC Developmental Biology, 7, 74. https://doi.org/10.1186/1471-213X-7-74

Müller, D., & Kontermann, R. E. (2007). Recombinant bispecific antibodies for cellular cancer immunotherapy. Current Opinion in Molecular Therapeutics, 9, Article 4. https://www.ncbi.nlm.nih.gov/pubmed/17694444

Eiseler, T., Schmid, M. A., Topbas, F., Pfizenmaier, K., & Hausser, A. (2007). PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Letters, 581, Article 22. https://doi.org/10.1016/j.febslet.2007.07.079

Stork, R., Müller, D., & Kontermann, R. E. (2007). A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Engineering, Design and Selection, 20, Article 11. https://doi.org/10.1093/protein/gzm061

T, F., A, H., P, S., S, S., K, P., & MA, O. (2007). Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200612017

Olayioye, M. A., Buchholz, M., Schmid, S., Schöffler, P., Hoffmann, P., & Pomorski, T. (2007). Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. Journal of Biological Chemistry, 282, Article 31. https://doi.org/10.1074/jbc.M701990200

D, M., AC, N., H, G., A, H., SJ, K., I, W., & A, P. (2007). Protein kinase D regulates several aspects of development in Drosophila melanogaster. BMC Developmental Biology. https://doi.org/10.1186/1471-213x-7-74

Gerspach, J., Müller, D., Münkel, S., Selchow, O., Nemeth, J., Noack, M., Petrul, H., Menrad, A., Wajant, H., & Pfizenmaier, K. (2006). Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug. Cell Death and Differentiation, 13, Article 2. https://doi.org/10.1038/sj.cdd.4401735

Kontermann, R. E. (2006). Immunoliposomes for cancer therapy. Current Opinion in Molecular Therapeutics, 8, Article 1. http://www.ncbi.nlm.nih.gov/pubmed/16506524

Rüger, R., Müller, D., Fahr, A., & Kontermann, R. E. (2006). In vitro characterization of binding and stability of single-chain Fv Ni-NTA-liposomes. Journal of Drug Targeting, 14, Article 8. https://doi.org/10.1080/10611860600864018

A, H., G, L., M, H., C, R., O, S., & K, P. (2006). Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. Journal of Cell Science. https://doi.org/10.1242/jcs.03104

Beisner, J., Buck, M. B., Fritz, P., Dippon, J., Schwab, M., Brauch, H., Zugmaier, G., Pfizenmaier, K., & Knabbe, C. (2006). A Novel Functional Polymorphism in the Transforming Growth Factor-β2 Gene Promoter and Tumor Progression in Breast Cancer. Cancer Research, 66, Article 15. https://doi.org/10.1158/0008-5472.CAN-06-0634

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