Review accepted in Cellular Signalling
Multi-level control of actin dynamics by protein kinase D
Monilola A. Olayioye, Sandra Barisic, Angelika Hausser*
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569
Stuttgart, Germany
*corresponding author, angelika.hausser@izi.uni-stuttgart.de, phone 0049-711-6856-6995, fax
0049-711-6856-7484
Abstract:
Dynamic actin remodeling is fundamental to processes such as cell motility, vesicle
trafficking, and cytokinesis. Protein kinase D (PKD) is a serine-threonine kinase known to be
involved in diverse biological functions ranging from vesicle fission at the Golgi complex to
regulation of cell motility and invasion. This review addresses the role of PKD in the organization
of the actin cytoskeleton with a particular emphasis on the substrates associated with this
function. We further highlight the multi-level control of actin dynamics by PKD and suggest that
the tight spatio-temporal control of PKD activity is critical for the coordination of directed cell
migration.